2746-81-8
中文名稱
氟奮乃靜庚酸酯
英文名稱
fluphenazine O-enantate
CAS
2746-81-8
分子式
C29H38F3N3O2S
分子量
549.698
MOL 文件
2746-81-8.mol
2746-81-8 結(jié)構(gòu)式
基本信息
中文別名
氟奮乃靜庚酸酯癸氟奮乃靜雜質(zhì)C(EP)
氟奮乃靜庚酸鹽 EP標(biāo)準(zhǔn)品
氟奮乃靜癸酸酯雜質(zhì)C (EP)
癸氟奮乃靜雜質(zhì)3(癸氟奮乃靜EP雜質(zhì)C)
英文別名
moditen enanthatefluphenazine O-enantate
Fluphenazine enantate CRS
Fluphenazine Decanoate Impurity 3 (Fluphenazine Decanoate EP Impurity C)
2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl heptanoate
2-[4-[3-[2-(Trifluoromethyl)phenothiazin-10-yl]propyl]-1-piperazinyl]ethyl heptanoate
enanthic acid 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl ester
Heptanoic acid, 2-4-3-2-(trifluoromethyl)-10H-phenothiazin-10-ylpropyl-1-piperazinylethyl ester
所屬類別
化學(xué)試劑：肼物理化學(xué)性質(zhì)
熔點184.5°C
沸點629.4±55.0 °C(Predicted)
密度1.1661 (estimate)
溶解度Practically insoluble in water, very soluble in ethanol and in methylene chloride, freely soluble in methanol.
酸度系數(shù)(pKa)7.32±0.10(Predicted)
形態(tài)neat
常見問題列表
生物活性
Fluphenazine enanthate 是第一種長效抗精神病藥物，用于研究精神分裂癥。體內(nèi)研究
Fluphenazine enanthate (2,4, 8 mg/kg; IM) significant inhibition of the avoidance performance is observed as long as 16, 23, and 28 days, respectively.
Fluphenazine enanthate (8 mg/kg) drinking behavior is almost completely suppressed for 24 hours immediately following the administration.
Fluphenazine enanthate (8 mg/kg) produces transient body weight Iosses in the rats.
| Animal Model: | Fifty-four male adult rats of Wistar strain |
| Dosage: | 2, 4, and 8 mg/kg |
| Administration: | Index medicus (IM ) |
| Result: | Three doses of Fluphenazine enanthate significant inhibition of the avoidance performance was observed as long as 16, 23, and 28 days, respectively. |