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261969-05-5

中文名稱 H-VAL-LYS-PHE-GLY-VAL-GLY-PHE-LYS-OH
英文名稱 CALP3
CAS 261969-05-5
分子式 C44H68N10O9
分子量 881.07
MOL 文件 261969-05-5.mol
更新日期 2024/12/23 10:30:23
261969-05-5 結(jié)構(gòu)式 261969-05-5 結(jié)構(gòu)式

基本信息

中文別名
CALP3 三氟乙酸鹽
H-VAL-LYS-PHE-GLY-VAL-GLY-PHE-LYS-OH
英文別名
CALP3
Calcium-like peptide 3
Calcium-Like Peptide 3,CALP-3
L-Lysine, L-valyl-L-lysyl-L-phenylalanylglycyl-L-valylglycyl-L-phenylalanyl-
Calcium-Like Peptide 3 trifluoroacetate salt H-Val-Lys-Phe-Gly-Val-Gly-Phe-Lys-OH trifluoroacetate salt

物理化學(xué)性質(zhì)

儲存條件Desiccate at -20°C
形態(tài)Powder
顏色White to off-white
水溶解性Soluble to 1 mg/ml in water
H-VAL-LYS-PHE-GLY-VAL-GLY-PHE-LYS-OH價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-P1075H-VAL-LYS-PHE-GLY-VAL-GLY-PHE-LYS-OH
CALP3
261969-05-51mg550元
2024/11/08HY-P1075H-VAL-LYS-PHE-GLY-VAL-GLY-PHE-LYS-OH
CALP3
261969-05-55mg1700元
2024/11/08HY-P1075H-VAL-LYS-PHE-GLY-VAL-GLY-PHE-LYS-OH
CALP3
261969-05-510mg2500元

常見問題列表

生物活性
CALP3 是一種類似于 Ca2+ 的肽,是有效的 Ca2+ 通道阻滯劑,可激活 Ca2+ 結(jié)合蛋白的 EF 手。CALP3 可以通過調(diào)節(jié)鈣調(diào)蛋白 (CaM),Ca2+ 通道和泵的活性來模擬增加的 [Ca2+]i。CALP3 具有控制諸如艾滋病或由于缺血引起的神經(jīng)元丟失等疾病中細(xì)胞凋亡的潛力。
靶點(diǎn)

Ca 2+

體外研究

CALP3 (50, 100, 150, 200 μM) inhibits glutamate caused a large sustained increase in [Ca 2+ ] i in a dose-dependent manner (IC 50 =37.25 μM) in Fura-2-loaded neuronal cultures.
CALP3 (50, 100, 150, 200 μM) inhibits glutamate-induced cytotoxicity in a dose-dependent manner (IC 50 =50.97 μM) in cultured rat neocortical neurons. CALP3 causes dose-dependent inhibition of apoptosis (IC 50 =33.41 μM).
CALP3 (100 μM) inhibits apoptosis induced by HIV gp120 and SAg in Human T cells.
CALP3 (100?μM; 15?min pretreatment) reduces gossypol-induced necrosis and increases the fraction of live cells.
Cyclic-CALP3 is synthesized starting from Fmoc-Asp(PEG-PS)-OAl. Cyclic CALP3 is unable to inhibit Ca21 influx, and this peptide served as a negative control. Cyclic CALP3 does not inhibit the effect of glutamate.

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