259674-19-6
中文名稱
259674-19-6
英文名稱
TRPM8 Antagonist
CAS
259674-19-6
分子式
C26H26N2O2
分子量
398.5
MOL 文件
259674-19-6.mol
更新日期
2023/07/03 08:49:47
259674-19-6 結(jié)構(gòu)式
基本信息
中文別名
化合物TRPM8 ANTAGONIST 2TRPM8 ANTAGONIST 2 游離
(S)-2-(二芐氨基)-3-(1H-吲哚-3-基)丙酸甲酯
英文別名
TRPM8 AntagonistTRPM8 antagonist 2
TRPM8 ANTAGONIST
259674-19-6
Methyl N,N-dibenzyl-L-tryptophanate
L-Tryptophan, N,N-bis(phenylmethyl)-, methyl ester
所屬類別
生物：拮抗劑物理化學(xué)性質(zhì)
沸點(diǎn)567.5±50.0 °C(Predicted)
密度1.195±0.06 g/cm3(Predicted)
儲(chǔ)存條件Inert atmosphere,2-8°C
溶解度DMSO : 160 mg/mL (401.51 mM)
酸度系數(shù)(pKa)17.02±0.30(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
TRPM8 拮抗劑價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-112430 | 259674-19-6 TRPM8 antagonist 2 | 259674-19-6 | 5mg | 900元 |
| 2024/11/08 | HY-112430 | 259674-19-6 TRPM8 antagonist 2 | 259674-19-6 | 10mM * 1mLin DMSO | 990元 |
| 2024/11/08 | HY-112430 | 259674-19-6 TRPM8 antagonist 2 | 259674-19-6 | 10mg | 1500元 |
常見問題列表
生物活性
TRPM8 antagonist 2 (TRPM8 Antagonist)是一種有效的 TRPM8 的拮抗劑，IC50值為0.2 nM，可用于神經(jīng)性疼痛綜合征的藥理治療。靶點(diǎn)
| Target | Value |
|
TRPM8
(Cell-free assay) | 0.2 nM |
體外研究
TRPM8 antagonist 2 (Compound 14) is a potent and selective TRPM8 antagonist, with an IC 50 of 0.2 nM, used in the research of neuropathic pain syndromes. TRPM8 antagonist 2 potently inhibits menthol-induced increase in intracellular Ca 2+ levels in Ca 2+ fluorimetric assays in HEK293 cells stably expressing the rat isoform of TRPM8 channels (IC 50 , 40 nM).
體內(nèi)研究
TRPM8 antagonist 2 (1, 10, and 30 mg/kg, s.c.) shows a marked, dose-dependent antinociceptive activity, and inhibits wet-dog shakes (WDS)-like cold hypersensitivity in mice by 63% at 30 mg/kg. In addition, TRPM8 antagonist 2 (0.1 and 1 μg, s.c.) attenuates Oxaliplatin (OXP)-induced cold allodynia in mice.