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256925-03-8

中文名稱 AL 082D06游離態(tài)
英文名稱 D 06
CAS 256925-03-8
分子式 C23H24ClN3O2
分子量 409.91
MOL 文件 256925-03-8.mol
更新日期 2024/12/23 17:39:04
256925-03-8 結(jié)構(gòu)式 256925-03-8 結(jié)構(gòu)式

基本信息

中文別名
AL 082D06游離態(tài)
英文別名
D 06
AL082D06
AL-082D06
AL 082D06
AL 082D06(D-06)
AL-082D06
D06
D-06
AL082D06
4,4'-[(2-Chloro-5-nitrophenyl)methylene]bis[N,N-dimethylbenzenamine]
Benzenamine, 4,4'-[(2-chloro-5-nitrophenyl)methylene]bis[N,N-dimethyl-
4-[(2-Chloro-5-nitrophenyl)-[4-(dimethylamino)phenyl]methyl]-N,N-dimethylaniline
所屬類別
生物化工:激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

沸點(diǎn)543.7±50.0 °C(Predicted)
密度1.232±0.06 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,2-8°C
溶解度DMSO:6.25(Max Conc. mg/mL);15.25(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);24.4(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.81(Max Conc. mM)
酸度系數(shù)(pKa)5.36±0.24(Predicted)
形態(tài)結(jié)晶固體
顏色Light yellow to yellow
AL 082D06游離態(tài)價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08S6608AL 082D06游離態(tài)
AL082D06
256925-03-82mg2269.2元
2024/11/08HY-15709AL 082D06游離態(tài)
AL 082D06
256925-03-82mg2000元
2024/11/08S6608AL 082D06游離態(tài)
AL082D06
256925-03-85mg3497.49元

常見問題列表

生物活性
AL082D06是非類固醇的糖皮質(zhì)激素受體拮抗劑,而對(duì)與其高度相關(guān)受體如鹽皮質(zhì)激素、雄激素、雌激素和孕酮等無顯著結(jié)合親和力。
靶點(diǎn)
TargetValue
Glucocorticoid receptor
()
210 nM(Ki)
體外研究

AL 082D06 (D06) binds specifically to GR with nanomolar affinity. Addition of AL 082D06 causes a dose-dependent decrease in transcriptional activation from the MMTV:Luc reporter stimulated with half-maximal DEX concentrations. AL 082D06 acts to antagonize reporter activity using several glucocorticoid-responsive promoter- reporter systems including the 3-kb tyrosine amino transferase (TAT) promoter and less complex promoters comprised of isolated glucocorticoid response element (GRE) sequences. AL 082D06 competes with 3 H-Dex for baculovirus-expressed GR with nanomolar affinity. Other intracellular receptors (AR, ER, PR, and MR) have no affinity for AL 082D06 in a similarly structured binding assay with the appropriate receptor and tritiated ligand (>2500 nM). AL 082D06 has no activation efficacy on the progesterone, androgen, mineralocorticoid, retinoid, glucocorticoid, or estrogen receptors. AL 082D06 is very efficacious at antagonizing GR activity but exhibits much weaker efficacy when tested against the other steroid receptors in contrast to the reference antagonists used as controls.

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