255730-18-8
255730-18-8 結(jié)構(gòu)式
基本信息
中文別名
青蒿酮 英文別名
ArtemisoneArtemifone
BAY 44-9585
YHVQDGXHTCSGBJ-AKSSTEKGSA-N
10alpha-[4'-(S,S-Dioxothiomorpholin-1'-yl)]-10-deoxodihydroartemisinin
4-[(3R,5aS,6R,8aS,9R,10R,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]thiomorpholine 1,1-dioxide
Thiomorpholine, 4-[(3R,5aS,6R,8aS,9R,10R,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]-, 1,1-dioxide
物理化學(xué)性質(zhì)
沸點(diǎn)536.5±50.0 °C(Predicted)
密度1.33±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : 130 mg/mL (323.77 mM)
酸度系數(shù)(pKa)2.99±0.20(Predicted)
形態(tài)Solid
顏色White to off-white
青蒿酮價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-19502 | 青蒿酮 Artemisone | 255730-18-8 | 5mg | 2891元 |
| 2024/11/08 | HY-19502 | 青蒿酮 Artemisone | 255730-18-8 | 10mM * 1mLin DMSO | 3180元 |
| 2024/11/08 | HY-19502 | 青蒿酮 Artemisone | 255730-18-8 | 10 mg | 4100元 |
常見(jiàn)問(wèn)題列表
生物活性
Artemisone (Artemifone) 是一種有效、半合成的抗瘧疾劑，能夠抑制多種 P. falciparum，平均 IC50 值為 0.83 nM。Artemisone 還是一種人 CMV 的有效抑制劑。靶點(diǎn)
IC50: 0.83 nM ( P. falciparum )
體外研究
Artemisone inhibits 3D7 and K1 P. falciparum , with IC 50 s of 0.88±0.59 and 1.23±0.64 nM, respectively.
體內(nèi)研究
Artemisone is effectve at inhibiting the parasitaemia in the
P. berghei
NY susceptible strain, with an ED
50
of 9.62 mg/kg via subcutaneous route and 11.67 mg/kg via oral administration.
Artemisone (3, 1, 0.3 and 0.1 mg/kg, s.c.) in combination with ohter antimalarials has enhanced effect against the chloroquine-resistant line
P. yoelii
NS