2553217-91-5
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BSH-IN-1 (Compound?7) also?inhibits BSH activity in growing cultures of Gram-negative ( B. theta VPI-5482, Bacteroides fragilis ATCC 25285, and Bacteroides vulgatus ATCC 8482) and Gram-positive ( Lactobacillus plantarum WCFS1, C. perfringens ATCC 13124, and Bifidobacterium adolescentis L2-32) bacteria.?BSH-IN-1 (Compound?7) also is a potent BSH inhibitor in growing bacterial cultures with IC 50 s of 237 nM and 1070 nM for B. adolescentis (Gram positive) and B. theta (Gram negative), respectively.
BSH-IN-1 (Compound 7; 10?mg/kg; a single dose; gavage) inhibits BSH activity in C57BL/6 mice and can be gut-restricted.
| Animal Model: | C57BL/6 mice |
| Dosage: | 10?mg/kg |
| Administration: | Single gavage |
| Result: | Inhibited gut bacterial BSH activity and modulated the bile acid pool in vivo while not significantly affected the gut bacterial community. |