251994-14-6
中文名稱
251994-14-6
英文名稱
Thieno[2,3-c]pyridine-2-carboxamide, 4-(4-bromophenoxy)-N-methyl-
CAS
251994-14-6
分子式
C15H11BrN2O2S
分子量
363.23
MOL 文件
251994-14-6.mol
更新日期
2024/12/22 16:36:08
251994-14-6 結(jié)構(gòu)式
基本信息
中文別名
化合物 T13147化合物ICAM-1-IN-1
英文別名
CAM-IN-1ICAM-1 inhibitor 1
Thieno[2,3-c]pyridine-2-carboxamide, 4-(4-bromophenoxy)-N-methyl-
物理化學(xué)性質(zhì)
熔點(diǎn)78-80 °C
沸點(diǎn)579.6±45.0 °C(Predicted)
密度1.556±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : ≥ 135 mg/mL (371.67 mM)
酸度系數(shù)(pKa)13.70±0.46(Predicted)
形態(tài)Solid
顏色White to off-white
常見(jiàn)問(wèn)題列表
生物活性
ICAM-1-IN-1 是有效，選擇性的 E-selectin 和 ICAM-1 抑制劑，IC50值分別為7和5 nM。靶點(diǎn)
IC50: 7 nM (E-selectin), 5 nM (ICAM-1)
體內(nèi)研究
ICAM-1-IN-1 shows significant efficacy in a rat rheumatoid arthritis model and in a mouse asthma model. ICAM-1-IN-1 reduces the width of inflamed ankles after the ninth day following treatment, but shows no efficacy in the acute phase. Treatment with ICAM-1-IN-1 (25 mg/kg) for 21 days significantly reduces the ankle inflammation of the arthritis rats. Significant reduction of eosinophils and serum-soluble ICAM-1 (sICAM-1) is observed.