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249537-73-3

中文名稱 NFAT INHIBITOR
英文名稱 H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH
CAS 249537-73-3
分子式 C75H118N20O22S
分子量 1683.93
MOL 文件 249537-73-3.mol
更新日期 2024/12/22 20:23:43
249537-73-3 結(jié)構(gòu)式 249537-73-3 結(jié)構(gòu)式

基本信息

中文別名
化合物AGI-5198
11R-VIVIT游離態(tài)
NFAT INHIBITOR-1
細(xì)胞滲透性肽抑制劑多肽H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH
L-蛋氨酰-L-丙氨酰甘氨酰-L-脯氨酰-L-組氨酰-L-脯氨酰-L-纈氨酰-L-異亮氨酰-L-纈氨酰-L-異亮氨酰-L-蘇氨酰甘氨酰-L-脯氨酰-L-組氨酰-L-ALPHA-谷氨酰-L-谷氨酸
英文別名
VIVIT
NFAT INHIBITOR
MAGPHPVIVITGPHEE
NFAT INHIBITOR?, >98%
NFAT Inhibitor (VIVIT peptide)
NFAT Inhibitor >96% (HPLC), solid
NFAT Inhibitor,VIVIT peptide,MAGPHPVIVITGPHEE?, >98%
MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU
H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH
L-Glutamic acid, L-methionyl-L-alanylglycyl-L-prolyl-L-histidyl-L-prolyl-L-valyl-L-isoleucyl-L-valyl-L-isoleucyl-L-threonylglycyl-L-prolyl-L-histidyl-L-α-glutamyl-
所屬類別
生物化工:激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

沸點(diǎn)1982.4±65.0 °C(Predicted)
密度1.334±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C
溶解度DMSO: 15 mg/ml; Water: 10 mg/ml
酸度系數(shù)(pKa)3.12±0.10(Predicted)
形態(tài)solid
顏色White to off-white
水溶解性Soluble to 2 mg/ml in water
序列H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
安全說明22-24/25
WGK Germany3
WGK Germany3
海關(guān)編碼2933299090
NFAT INHIBITOR價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-P1026NFAT INHIBITOR
NFAT Inhibitor
249537-73-31mg700元
2024/11/08HY-P1026NFAT INHIBITOR
NFAT Inhibitor
249537-73-35mg2800元
2024/11/08HY-P1026NFAT INHIBITOR
NFAT Inhibitor
249537-73-310mg5100元

常見問題列表

生物活性
NFAT Inhibitor (VIVIT peptide) 是一種 NFAT 的細(xì)胞滲透性肽抑制劑,可選擇性抑制鈣調(diào)磷酸酶介導(dǎo)的 NFAT 脫磷酸作用。
靶點(diǎn)

Nuclear factor of activated Tcells (NFAT)

體外研究

NFAT Inhibitor treatment significantly inhibits nuclear translocation of NFATc1 for 24 hours. Long-term treatment with VIVIT significantly inhibits the cytoplasmic levels of cathepsin K, TRAP, and MMP-9.

Western Blot Analysis

Cell Line: Human peripheral blood CD14 + monocytes
Concentration: 10 μM
Incubation Time: 24 hours or 21 days
Result: Short-term treatment with 10 μM, significantly inhibited nuclear translocation of NFATc1. Long-term treatment, significantly inhibited the cytoplasmic levels of cathepsin K, TRAP, and MMP-9.
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