2416095-00-4
英文名稱
Glycine, N-[(3R,4S)-4-[(3,4-dichlorophenyl)sulfonyl]tetrahydro-1,1-dioxido-3-thienyl]-, rel-
CAS
2416095-00-4
分子式
C12H13Cl2NO6S2
分子量
402.27
MOL 文件
2416095-00-4.mol
2416095-00-4 結(jié)構(gòu)式
基本信息
英文別名
CBR-470-2Glycine, N-[(3R,4S)-4-[(3,4-dichlorophenyl)sulfonyl]tetrahydro-1,1-dioxido-3-thienyl]-, rel-
物理化學(xué)性質(zhì)
沸點734.1±60.0 °C(Predicted)
密度1.71±0.1 g/cm3(Predicted)
儲存條件4°C, stored under nitrogen
溶解度DMSO: 200 mg/mL (497.18 mM)
酸度系數(shù)(pKa)2.34±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
CBR-470-2 是甘氨酸取代的類似物，可以激活 NRF2 信號傳導(dǎo)。CBR-470-2 可用于調(diào)節(jié)糖酵解。靶點
NRF2
體外研究
CBR-470-2 (1-10 μM; 24 h) increases transcript levels of the NRF2-responsive genes NQO1 and HMOX1 in epidermal keratinocytes and dermal fibroblasts.
體內(nèi)研究
CBR-470-2 (50 mg/kg; p.o. twice daily for 10 d) induces activation of NRF2 signaling in vivo.
| Animal Model: | Balb/C mice (5-week old) are exposed to UVB |
| Dosage: | 50 mg/kg |
| Administration: | P.o. twice daily for 10 days |
| Result: |
Resulted in comparable beneficial effects on erythema histological scores and total wounded area.
Decreased epidermal thickness in response to UV exposure. |