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2407860-35-7

中文名稱 化合物ERSO
英文名稱 2H-Indol-2-one, 1,3-dihydro-3-(4-hydroxyphenyl)-3-[4-(trifluoromethoxy)phenyl]-7-(trifluoromethyl)-, (3R)-
CAS 2407860-35-7
分子式 C22H13F6NO3
分子量 453.33
MOL 文件 2407860-35-7.mol
2407860-35-7 結(jié)構(gòu)式 2407860-35-7 結(jié)構(gòu)式

基本信息

中文別名
化合物ERSO
化合物 ERSO-DFP
英文別名
ErSO
ErSo-DFP
2H-Indol-2-one, 1,3-dihydro-3-(4-hydroxyphenyl)-3-[4-(trifluoromethoxy)phenyl]-7-(trifluoromethyl)-, (3R)-

物理化學(xué)性質(zhì)

沸點(diǎn)485.0±45.0 °C(Predicted)
密度1.461±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)9?+-.0.30(Predicted)
形態(tài)Solid
顏色White to off-white

應(yīng)用領(lǐng)域

用途一
ErSO is an activator of the unfolded protein response which eradicates human breast tumors in mice. ErSO activates the anticipatory unfolded protein response (a-UPR) and induces rapid and selective necrosis of ERα-positive breast cancer cell lines in vitro. In multiple orthotopic models, ErSO treatment given either orally or intraperitoneally for 14 to 21 days induced tumor regression without recurrence. In a cell line tail vein metastasis model, ErSO was also effective at inducing regression of most lung, bone, and liver metastases. ErSO treatment induced almost complete regression of brain metastases in mice carrying intracranial human breast cancer cell line xenografts.
化合物ERSO價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-144070ErSO-DFP2407860-35-75 mg2600元
2024/11/08HY-132247ErSO2407860-35-75 mg2900元
2024/11/08HY-144070ErSO-DFP2407860-35-710 mg4200元
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