24003-58-5
24003-58-5 結(jié)構(gòu)式
基本信息
[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium:bromide
2-[(2,6-DIMETHYLPHENYL)AMINO]-N,N,N-TRIETHYL-2-OXO-ETHANAMINIUM BROMIDE
物理化學(xué)性質(zhì)
常見問題列表
sodium channel
QX-314 bromide exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro .
QX-314 bromide (1–60 mM) directly activates TRPV1 in a concentration-dependent manner.
QX-314 bromide (≥ 30 mM) produces oocyte membrane blackening and cell death .
QX-314 bromide inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca
2+
currents are on average < 10% of control amplitude .
QX-314 bromide shifts the current-voltage relationships (I-Vs) in the positive voltage direction due to the presence of intracellular Br- .
QX-314 bromide (1.6 mg/kg; i.c.) abolishes responses to noxious mechanical and thermal stimuli without motor or tactile deficits when co-treatment with capsaicin.
| Animal Model: | Male Sprague-Dawley rats (250-290 g) |
| Dosage: | 1.6 mg/kg |
| Administration: | Intracutaneous injection |
| Result: | Abolished responses to noxious mechanical and thermal stimuli without motor or tactile deficits when co-treatment with capsaicin. |