23567-97-7
23567-97-7 結(jié)構(gòu)式
常見問題列表
生物活性
8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate)，一種 ATP 類似物，是一種嘌呤能 P2X receptor 受體的激動劑。8-Bromo-ATP 對多發(fā)性骨髓瘤細胞具有細胞毒性，IC50 為 23.1 μM。體外研究
8-Bromo-ATP (10-50 μM; 5 days) treatment shows cytotoxic to multiple myeloma.
Fluorescence measurements are made possible through the use of 8-Bromo-ATP, which selectively quenched certain tryptophan residues of the ATPase. 8-Bromo-ATP enhances the rate of dephosphorylation of native ATPase 2-3-fold when added in the absence of divalent cations.
Cell Viability Assay
| Cell Line: | MM 1.s cells |
| Concentration: | 10 μM, 20 μM, 30 μM, 40 μM, 50 μM |
| Incubation Time: | 5 days |
| Result: | Showed cytotoxic to multiple myeloma. |