23555-00-2
中文名稱
HOECHST 34580
英文名稱
HOECHST 34580
CAS
23555-00-2
分子式
C27H29N7
分子量
451.57
MOL 文件
23555-00-2.mol
更新日期
2024/10/31 09:35:13
23555-00-2 結(jié)構(gòu)式
基本信息
英文別名
ProaMineHOE 34580
HOECHST 34580
2,50-bibenzimidazole, 20-[p-(dimethylamino)phenyl]-5-(4-methyl-1-piperazinyl)-
Benzenamine, N,N-dimethyl-4-[5-(4-methyl-1-piperazinyl)[2,5'-bi-1H-benzimidazol]-2'-yl]-
所屬類別
生物化工：熒光成像物理化學(xué)性質(zhì)
熔點(diǎn)>300℃
儲存條件Keep in dark place,Sealed in dry,2-8°C
溶解度溶于二甲亞砜、水
酸度系數(shù)(pKa)10.97±0.10, most acidic, temperature:
25 °C; 7.66 ± 0.42, most basic(at 25℃)
形態(tài)粉末
顏色黃色到綠色
最大波長(λmax)392nm
生物領(lǐng)域應(yīng)用Detecting malaria infected red blood cells,polynucleotides; nucleic acid amplification; nucleic acid sequencing
HOECHST 34580價(jià)格(試劑級)
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2024/11/08 | S0486 | HOECHST 34580 Hoechst 34580 | 23555-00-2 | 5mg | 2047.06元 |
| 2024/11/08 | S0486 | HOECHST 34580 Hoechst 34580 | 23555-00-2 | 25mg | 6445.63元 |
| 2023/03/20 | HY-15560 | HOECHST 34580 Hoechst 34580 | 23555-00-2 | 5mg | 600元 |
常見問題列表
生物活性
Hoechst 34580 (HOE 34580) 是一種具有細(xì)胞滲透性的藍(lán)色熒光染料，用于染色DNA和細(xì)胞核。Hoechst 34580 也是一種治療阿爾茨海默病的良好候選者，通過抑制 amyloid beta (Aβ) 的形成，其IC50值為0.86 μM。靶點(diǎn)
| Target | Value |
|
Aβ
(Cell-free assay) | 0.86 μM |
體外研究
Hoechst 34580 prefers to locate near hydrophobic regions with binding affinity with the inhibition constant IC 50 of 0.86±0.05 μM for Hoechst 34580. Hoechst 34580 is a good candidate for treating the Alzheimer’s disease by inhibiting Aβ formation. 50 μM Aβ42 solutions co-incubated with 100, 25, 12.5, 3.125, 0.78, and 0.1, 0.01 μM Hoechst 34580 at 37 °C for 70 h. Hoechst 34580 can inhibit the aggregation of Aβ42 in a dose-dependent manner. And the half-maximal concentration (IC 50 ) is examined. The IC 50 is obtained by measuring the concentration of Hoechst 34580 while maintaining the Aβ42 concentration which gave 0.86±0.05 μM for Hoechst 34580.