2349368-16-5
中文名稱
Benzeneacetamide, 4-(ethylsulfonyl)-N-[2'-fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]-
英文名稱
Benzeneacetamide, 4-(ethylsulfonyl)-N-[2'-fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]-
CAS
2349368-16-5
分子式
C25H20F7NO4S
分子量
563.48
MOL 文件
2349368-16-5.mol
2349368-16-5 結構式
基本信息
中文別名
XY101化合物 T13362
英文別名
XY101Benzeneacetamide, 4-(ethylsulfonyl)-N-[2'-fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]-
物理化學性質
沸點682.4±55.0 °C(Predicted)
密度1.439±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO: 250 mg/mL (443.67 mM)
酸度系數(shù)(pKa)8.87±0.19(Predicted)
形態(tài)Solid
顏色Off-white to light yellow
應用領域
用途一
XY101 is a Potent, Selective, and Orally Bioavailable RORγ Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer with IC50 = 30nM. XY101 potently inhibited cell growth, colony formation, and the expression of AR, AR-V7, and PSA. XY101 also exhibited good metabolic stability and a pharmacokinetic profile with oral bioavailability of 59% and a half-life of 7.3 h. Notably, XY101 demonstrated promising therapeutic effects with significant tumor growth inhibition in a prostate cancer xenograft model inmice.