2300982-44-7
中文名稱
RIPK1-IN-7
英文名稱
RIPK1-IN-7
CAS
2300982-44-7
分子式
C25H22F3N5O2
分子量
481.47
MOL 文件
2300982-44-7.mol
2300982-44-7 結(jié)構(gòu)式
基本信息
中文別名
化合物RIPK1-IN-7 英文別名
RIPK1-IN-7RIPK1 inhibitor 7
Ethanone, 1-[5-(4-amino-7-ethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-(trifluoromethoxy)phenyl]-
物理化學(xué)性質(zhì)
沸點(diǎn)724.8±60.0 °C(Predicted)
密度1.42±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 62.5 mg/mL (129.81 mM); Water: < 0.1 mg/mL (insoluble)
酸度系數(shù)(pKa)5.76±0.30(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
常見問題列表
生物活性
RIPK1-IN-7 是受體相互作用蛋白激酶 1 (RIPK1) 抑制劑，Kd 值為 4 nM，IC50 值為 11 nM。RIPK1-IN-7 在 實(shí)驗(yàn)性 B16 黑色素瘤肺轉(zhuǎn)移模型中具有良好的抗轉(zhuǎn)移活性。靶點(diǎn)
IC50: 11 nM (RIPK1)
Kd: 4 nM (RIPK1)
體外研究
RIPK1-IN-7 shows potent cell protection effect in the TSZ-induced HT29 cell necroptosis model with an EC
50
of 2nM.
RIPK1-IN-7 displays considerable activity against several other kinases, such as Flt4, TrkA, TrkB, TrkC, Axl, HRI, Mer, and MAP4K5 with IC
50
s of 20, 26, 8, 7, 35, 26, 29, and 27 nM, respectively.