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229971-81-7

中文名稱(chēng) N-鈣粘蛋白拮抗劑
英文名稱(chēng) ADH 1
CAS 229971-81-7
分子式 C22H34N8O6S2
分子量 570.69
MOL 文件 229971-81-7.mol
更新日期 2024/12/22 20:23:44
229971-81-7 結(jié)構(gòu)式 229971-81-7 結(jié)構(gòu)式

基本信息

中文別名
ADH 1游離態(tài)
N-鈣粘蛋白拮抗劑
化合物EXHERIN
(4R,7S,10S,13S,16R)-13-((1H-咪唑-5-基)甲基)-16-乙酰氨基-7-異丙基-10-甲基-6,9,12,15-四氧基-1,2-二硫基-5,8,11,14-四氮雜環(huán)庚烷-4-酰胺
英文別名
ADH 1
Exherin
CS-2142
Exherin TFA
ADH-1 Exherin
Exherin (ADH-1)
L-Cysteinamide, N-acetyl-L-cysteinyl-L-histidyl-L-alanyl-L-valyl-, cyclic (1→5)-disulfide
所屬類(lèi)別
生物化工:激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

沸點(diǎn)1183.4±65.0 °C(Predicted)
密度1.40±0.1 g/cm3(Predicted)
儲(chǔ)存條件Keep in dark place,Sealed in dry,Store in freezer, under -20°C
溶解度DMSO:2.2(Max Conc. mg/mL);3.86(Max Conc. mM)
酸度系數(shù)(pKa)13.13±0.70(Predicted)
形態(tài)A solid
顏色White to off-white
N-鈣粘蛋白拮抗劑價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2024/11/08HY-13541(4R,7S,10S,13S,16R)-13-((1H-咪唑-5-基)甲基)-16-乙酰氨基-7-異丙基-10-甲基-6,9,12,15-四氧基-1,2-二硫基-5,8,11,14-四氮雜環(huán)庚烷-4-酰胺
ADH-1
229971-81-75mg1000元
2024/11/08HY-13541(4R,7S,10S,13S,16R)-13-((1H-咪唑-5-基)甲基)-16-乙酰氨基-7-異丙基-10-甲基-6,9,12,15-四氧基-1,2-二硫基-5,8,11,14-四氮雜環(huán)庚烷-4-酰胺
ADH-1
229971-81-710mg1700元
2024/11/08HY-13541(4R,7S,10S,13S,16R)-13-((1H-咪唑-5-基)甲基)-16-乙酰氨基-7-異丙基-10-甲基-6,9,12,15-四氧基-1,2-二硫基-5,8,11,14-四氮雜環(huán)庚烷-4-酰胺
ADH-1
229971-81-725mg3100元

常見(jiàn)問(wèn)題列表

生物活性
ADH-1 是一種 N-cadherin 的拮抗劑,能夠抑制 N-cadherin 介導(dǎo)的細(xì)胞黏附。
體外研究

ADH-1 (0.2 mg/mL) blocks collagen I-mediated changes in pancreatic cancer cells, and is highly effective at preventing cell motility that is induced by expression of N-cadherin. ADH-1 (0, 0.1, 0.2, 0.5 and 1.0 mg/mL) induces apoptosis in a dose-dependent and N-cadherin-dependent manner.

體內(nèi)研究

ADH-1 (50 mg/kg) significantly prevents tumor growth and metastasis in a mouse model for pancreatic cancer. ADH-1 prevents tumor cell invasion and metastasis in an orthotopic model for pancreatic cancer using N-cadherin overexpressing BxPC-3 cells. ADH-1, at the dosages evaluated, does not display either antiangiogenic activity in a rat aortic ring assay or antitumor potential in a PC3 subcutaneous xenograft tumor model. ADH-1 (10 mL/kg, i.p.) augmentation of melanoma tumor growth is overcome through its ability to make regionally infused melphalan more effective. ADH-1 mediated augmentation of melanoma tumor growth is not altered by regionally infused temozolomide. In A375, but not DM443 xenografts, ADH-1 treatment increases phosphorylation of AKT at serine 473. ADH-1 slightly diminishes N-cadherin expression in both xenografts.

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