229971-81-7
基本信息
N-鈣粘蛋白拮抗劑
化合物EXHERIN
(4R,7S,10S,13S,16R)-13-((1H-咪唑-5-基)甲基)-16-乙酰氨基-7-異丙基-10-甲基-6,9,12,15-四氧基-1,2-二硫基-5,8,11,14-四氮雜環(huán)庚烷-4-酰胺
Exherin
CS-2142
Exherin TFA
ADH-1 Exherin
Exherin (ADH-1)
L-Cysteinamide, N-acetyl-L-cysteinyl-L-histidyl-L-alanyl-L-valyl-, cyclic (1→5)-disulfide
物理化學(xué)性質(zhì)
報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
2024/11/08 | HY-13541 | (4R,7S,10S,13S,16R)-13-((1H-咪唑-5-基)甲基)-16-乙酰氨基-7-異丙基-10-甲基-6,9,12,15-四氧基-1,2-二硫基-5,8,11,14-四氮雜環(huán)庚烷-4-酰胺 ADH-1 | 229971-81-7 | 5mg | 1000元 |
2024/11/08 | HY-13541 | (4R,7S,10S,13S,16R)-13-((1H-咪唑-5-基)甲基)-16-乙酰氨基-7-異丙基-10-甲基-6,9,12,15-四氧基-1,2-二硫基-5,8,11,14-四氮雜環(huán)庚烷-4-酰胺 ADH-1 | 229971-81-7 | 10mg | 1700元 |
2024/11/08 | HY-13541 | (4R,7S,10S,13S,16R)-13-((1H-咪唑-5-基)甲基)-16-乙酰氨基-7-異丙基-10-甲基-6,9,12,15-四氧基-1,2-二硫基-5,8,11,14-四氮雜環(huán)庚烷-4-酰胺 ADH-1 | 229971-81-7 | 25mg | 3100元 |
常見(jiàn)問(wèn)題列表
ADH-1 (0.2 mg/mL) blocks collagen I-mediated changes in pancreatic cancer cells, and is highly effective at preventing cell motility that is induced by expression of N-cadherin. ADH-1 (0, 0.1, 0.2, 0.5 and 1.0 mg/mL) induces apoptosis in a dose-dependent and N-cadherin-dependent manner.
ADH-1 (50 mg/kg) significantly prevents tumor growth and metastasis in a mouse model for pancreatic cancer. ADH-1 prevents tumor cell invasion and metastasis in an orthotopic model for pancreatic cancer using N-cadherin overexpressing BxPC-3 cells. ADH-1, at the dosages evaluated, does not display either antiangiogenic activity in a rat aortic ring assay or antitumor potential in a PC3 subcutaneous xenograft tumor model. ADH-1 (10 mL/kg, i.p.) augmentation of melanoma tumor growth is overcome through its ability to make regionally infused melphalan more effective. ADH-1 mediated augmentation of melanoma tumor growth is not altered by regionally infused temozolomide. In A375, but not DM443 xenografts, ADH-1 treatment increases phosphorylation of AKT at serine 473. ADH-1 slightly diminishes N-cadherin expression in both xenografts.