229961-45-9
229961-45-9 結(jié)構(gòu)式
基本信息
CS-1211
VTP194310
VTP-194310
AGN 194310
VTP 194310
AGN-194310, 194310
AGN194310
AGN-194310
VTP194310
VTP 194310
VTP-194310
Benzoic acid, 4-[2-[4-(4-ethylphenyl)-2,2-dimethyl-2H-1-benzothiopyran-6-yl]ethynyl]-
物理化學(xué)性質(zhì)
常見問題列表
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RARα 3 nM (Kd) |
RARβ 2 nM (Kd) |
RARγ 5 nM (Kd) |
AGN194310 potently inhibits colony formation by all three lines, with IC50 values of 16 nM for LNCaP cells; 18 nM for PC3 cells; and 34 nM for DU-145 cells.
AGN 194310 (50 nM, 100 nM; LNCaP, PC-3 and DU-145 cells) inhibits colony formation at concentrations of 50 nM and 100 nM alone and in combination with TTNPB.
AGN 194310 (1 μM; 72 hours; LNCaP cells) treatment results in 80% apoptosis.
Cell Viability Assay
| Cell Line: | LNCaP, PC-3 and DU-145 cells. |
| Concentration: | 50 nM, 100 nM |
| Incubation Time: | |
| Result: | When used together with 100 nM TTNPB, there was almost complete reversal of the growth inhibitory effect of 50 nM and partial reversal of the effect of 100 nM. |
Apoptosis Analysis
| Cell Line: | LNCaP cells |
| Concentration: | 1 μM |
| Incubation Time: | 72 hours |
| Result: | Induced apoptosis in LNCaP cells. |
AGN 194310 (0.5 mg/kg/day; oral gavage; every day; for 10 days; female C57Bl/6J mice) treatment increases the number of granulocytes across haemopoietic compartments. A significant increase in the frequency of granulocyte-progenitor cells is observed in the bone marrow of mice after treatment with AGN194310.
| Animal Model: | Female C57Bl/6J mice (Five-week-old (34-37 days)) |
| Dosage: | 0.5 mg/kg/day |
| Administration: | Oral gavage; every day; for 10 days |
| Result: | The number of granulocytes was significantly increased across haemopoietic compartments. Progenitor cells containing granulocytes also increased significantly. |