2253744-53-3
基本信息
DJ-V159
DJ-V 159
1,3-Benzenedicarboxamide, N1,N3-bis[4-cyano-3-(trifluoromethyl)phenyl]-
物理化學(xué)性質(zhì)
報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
2024/11/08 | HY-114165 | DJ-V159 DJ-V-159 | 2253744-53-3 | 5mg | 420元 |
2024/11/08 | HY-114165 | DJ-V159 DJ-V-159 | 2253744-53-3 | 10mM * 1mLin DMSO | 464元 |
2024/11/08 | HY-114165 | DJ-V159 DJ-V-159 | 2253744-53-3 | 10mg | 686元 |
常見(jiàn)問(wèn)題列表
GPRC6A.
DJ-V-159 activates ERK in HEK-293 transfected with GPRC6A but not in non-transfected HEK-293 cells, with potency similar to L-Arg. In addition, DJ-V-159 dose-dependently stimulates cAMP production in GPRC6A expressing HEK-293 cells, achieving a response a 0.2 nM concentrations in the media. DJ-V-159 stimulates insulin secretion in mouse beta-cell MIN-6 cells. The DJ-V-159 increased insulin stimulation index (SI) in MIN-6 cells similar to the effects of Ocn, known ligand of GPRC6A.
DJ-V-159 at the dose of 10 mg/kg reduces blood glucose levels in wildtype mice at 60 and 90 minutes after intraperitoneal administration of 10 mg/kg, whereas the vehicle (95% PEG + 5% DMSO) has no effect on blood glucose. DJ-V-159 reduces blood glucose levels in wild-type mice by 43.6% and 41.9% at 60 and 90 minutes, respectively, after intraperitoneal administration of 10 mg/kg. The mice tolerated this short-term exposure to DJ-V-159 without any overt side-effects. DJ-V-159, however, is almost in or on the boundary of the Lipinski's Rule of Five.