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2250025-92-2

中文名稱 化合物 T11095
英文名稱 DREADD agonist 21 dihydrochloride
CAS 2250025-92-2
分子式 C17H19ClN4
分子量 314.82
MOL 文件 2250025-92-2.mol
2250025-92-2 結構式 2250025-92-2 結構式

基本信息

中文別名
化合物 T11095
英文別名
DREADD agonist 21 dihydrochloride

物理化學性質

溶解度Soluble to 100 mM in water and to 100 mM in DMSO
形態(tài)固體
顏色黃色
水溶解性Soluble in water (100mM). Always store solutions at -20°C.

常見問題列表

生物活性
DREADD agonist 21 dihydrochloride 是一種有效的人毒蕈堿乙酰膽堿 M3 受體 (hM3Dq) 激動劑 (EC50=1.7 nM)。
靶點

EC50: 1.7 nM (hM3Dq)
pKi: 5.97 (hM1), 5.44 (hM4), 7.20 (hM1Dq), and 6.75 (hM4Di)
Ki: 6 nM (H1 histamine receptor), 66 nM (5HT2A serotonin receptor 5HT2A), 170 nM (5HT2C serotonin receptor), 280 nM (α1A adrenergic receptor)

體外研究

DREADD agonist 21 is a potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist (EC 50 =1.7 nM) and does not activate human M3 receptor (hM3). In addition to being inactive at hM3, DREADD agonist 21, a potent full agonist of hM3Dq (EC 50 =1.7 nM), is only 3.5-fold selective for hM3Dq over H1, 40-fold selective over 5HT2A, 100-fold selective over 5HT2C, and 165-fold selective over α1A. DREADD agonist 21 shows high binding affinities to 5HT2A and 5HT2C serotonin receptor, α1A adrenergic receptor, and H1 histamine receptor with K i values of 66, 170, 280, and 6 nM, respectively.
DREADD agonist 21 potently activates hM1Dq, hM3Dq, and hM4Di. DREADD agonist 21 binds to hM1, hM4, hM1Dq and hM4Di receptors with pK i s of 5.97, 5.44, 7.20, and 6.75, respectively. DREADD agonist 21 potently activates hM3Dq in Chinese hamster ovary (CHO) cells transfected cells in vitro with a pEC 50 of 8.48±0.05. DREADD agonist 21 is a highly selective and potent agonist for muscarinic DREADDs (pEC 50 for hM1Dq=6.54 and that for hM4Di=7.77 in pERK assays).

體內研究

DREADD agonist 21 (0.3, 1.0, and 3.0 mg/kg; i.p.) activates neuronal hM3Dq in mice.
DREADD agonist 21 has excellent bioavailability, pharmacokinetic properties, and brain penetrability. DREADD agonist 21 (0.1, 1, and 10 mg/kg; i.p.) displays 95.1% plasma protein binding and 95% brain protein bounding in mice.

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