天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

返回ChemicalBook首頁>CAS數(shù)據(jù)庫列表>2248666-66-0

2248666-66-0

中文名稱 PF429242 DIHYDROCHLORIDE
英文名稱 PF429242 dihydrochloride
CAS 2248666-66-0
分子式 C??H??Cl?N?O?
更新日期 2024/12/23 09:08:14
分子量 446.03
MOL 文件 2248666-66-0.mol
2248666-66-0 結(jié)構(gòu)式 2248666-66-0 結(jié)構(gòu)式

基本信息

中文別名
PF 429242鹽酸鹽
化合物PF429242 DIHYDROCHLORIDE
(R)-4-((二乙氨基)甲基)-N-(2-甲氧基苯乙基)-N-(吡咯烷-3-基)苯甲酰胺二鹽酸鹽
英文別名
PF 429242-HCl
PF429242,PF-429242 dihydrochloride,PF429242 dihydrochloride,Virus Protease,inhibit,PF 429242,Inhibitor,Fatty Acid Synthase (FASN),PF-429242

物理化學(xué)性質(zhì)

儲存條件-20°C儲存
溶解度DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
形態(tài)結(jié)晶固體
顏色White to light brown

常見問題列表

生物活性
PF429242 dihydrochloride 是可逆的,競爭性的 SREBP 位點(diǎn) 1 蛋白酶 (S1P) 抑制劑,IC50 值為175 nM。
靶點(diǎn)

IC50: 175 nM (S1P)

體外研究

10 μM PF-429242 inhibits endogenous SREBP processing in Chinese hamster ovary cells. PF-429242 also down-regulates the signal from an SRE-luciferase reporter gene in human embryonic kidney 293 cells and the expression of endogenous SREBP target genes in cultured HepG2 cells. In HepG2 cells, PF-429242 inhibits cholesterol synthesis, with an IC 50 of 0.5 μM. The addition of PF-429242 (30 μM) shows statistically significant suppression of infectious viral titers and viral RNA copies in the cell culture fluids. PF-429242 treatment also shows suppressive effects on DENV2 yields in the cultured fluids of human-derived HEK-293, Hep G2, and non-human-primate derived LLC-MK2 cells. PF-429242 efficiently prevents the processing of GPC from the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) and LASV, which correlates with the compound's potent antiviral activity against LCMV and LASV in cultured cells.

體內(nèi)研究

In mice treated with PF-429242 for 24 h, the expression of hepatic SREBP target genes is suppressed, and the hepatic rates of cholesterol and fatty acid synthesis are reduced.

"2248666-66-0" 相關(guān)產(chǎn)品信息