223537-30-2
中文名稱
(2E,4S)-4-[(2R,5S)-2-(4-氟芐基)-6-甲基-5-(5-甲基異惡唑-3-基甲酰氨基)-4-氧代庚酰氨基]-5-[[(3S)-2-氧代-3-吡咯烷基]-2-戊烯酸乙酯
CAS
223537-30-2
分子式
C31H39FN4O7
分子量
598.66
MOL 文件
223537-30-2.mol
更新日期
2024/01/25 12:30:20
223537-30-2 結(jié)構(gòu)式
基本信息
中文別名
蘆平曲韋(2E,4S)-4-[(2R,5S)-2-(4-氟芐基)-6-甲基-5-(5-甲基異惡唑-3-基甲酰
2-(4-氟芐基)-6-甲基-5-(5-甲基異惡唑-3-基甲酰氨基)-4-氧代庚酰氨基]-5-[[(3S)-2-氧代-3-吡咯烷基]-2-戊烯酸乙酯
(2E,4S)-4-[(2R,5S)-2-(4-氟芐基)-6-甲基-5-(5-甲基異惡唑-3-基甲酰氨基)-4-氧代庚酰氨基]-5-[[(3S)-2-氧代-3-吡咯烷基]-2-戊烯酸乙酯
英文別名
AG 7088Aids121840
Rupintrivir
Aids-121840
Ruprintrivir
AG 7088 - Rupintrivir | Ruprintrivir
ethyl (E,4S)-4-[[(2R,5S)-2-[(4-fluorophenyl)methyl]-6-methyl-5-[(5-met hyloxazole-3-carbonyl)amino]-
(S,E)-Ethyl 4-((2R,5S)-2-(4-fluorobenzyl)-6-methyl-5-(5-methylisoxazole-3-carboxamido)-4-oxoheptanamido)-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoate
ethyl (E,4S)-4-[[(2R,5S)-2-[(4-fluorophenyl)methyl]-6-methyl-5-[(5-met hyloxazole-3-carbonyl)amino]-4-oxo-heptanoyl]amino]-5-[(3S)-2-oxopyrro lidin-3-yl]pent-2-enoate
(2E,4S)-4-[[(2R,5S)-2-[(4-Fluorophenyl)methyl]-6-methyl-5-[[(5-methyl-3-isoxazolyl)carbonyl]amino]-1,4-dioxoheptyl]amino]-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoic Acid
物理化學(xué)性質(zhì)
熔點(diǎn)170-171°C
密度1.213
儲(chǔ)存條件room temp
形態(tài)粉末
顏色白色至米色
旋光性 (optical activity)[α]/D +30 to +40°, c = 0.5 in chloroform-d
常見問題列表
生物活性
Rupintrivirvr (AG7088)，抗病毒藥，是一種有效，選擇性和不可逆的人類 rhinovirus (HRV) 3C protease 抑制劑。在 H1-Hela 和 MRC-5 細(xì)胞保護(hù)試驗(yàn)中，Rupintrivirvr 抑制48種不同HRV血清型的復(fù)制，平均 EC50 為 0.023 μM。Rupintrivirvr 具有免疫調(diào)節(jié)作用。體外研究
In H1-HeLa and MRC-5 cell protection assays, Rupintrivirvr (AG7088) inhibited the replication of all HRV serotypes (48 of 48) tested with a mean 50% effective concentration (EC 50 ) of 0.023 μM (range, 0.003 to 0.081 μM) and a mean EC 90 of 0.082 μM (range, 0.018 to 0.261 μM) as well as that of related picornaviruses including coxsackieviruses A21 and B3, enterovirus 70, and echovirus 11.
體內(nèi)研究
Rupintrivirvr (AG7088) reduces RV-induced TH-2 cytokine IL-4 in precision-cut lung slices (PCLS) of HDM-sensitized mice ex vivo.