2227372-56-5
中文名稱
(Z)-1-[2-CHLORO-2-(2,4-DICHLOROPHENYL)ETHENYL]-1H-1,2,4-TRIAZOLE HYDROCHLORIDE
英文名稱
(Z)-1-[2-CHLORO-2-(2,4-DICHLOROPHENYL)ETHENYL]-1H-1,2,4-TRIAZOLE HYDROCHLORIDE
CAS
2227372-56-5
分子式
C10H7Cl4N3
分子量
310.99
MOL 文件
2227372-56-5.mol
更新日期
2024/12/23 10:32:34
2227372-56-5 結(jié)構(gòu)式
基本信息
英文別名
LORECLEZOLE HYDROCHLORIDE(Z)-1-[2-CHLORO-2-(2,4-DICHLOROPHENYL)ETHENYL]-1H-1,2,4-TRIAZOLE HYDROCHLORIDE
物理化學(xué)性質(zhì)
溶解度Soluble to 5 mM in DMSO with gentle warming and to 5 mM in ethanol with gentle warming
常見問題列表
生物活性
Loreclezole hydrochloride 是一種抗癲癇化合物，是選擇性的 GABAA 受體 的調(diào)節(jié)劑，是β2 或β3亞單位包含受體的正向變構(gòu)調(diào)節(jié)劑。靶點(diǎn)
GABA A receptor.
體內(nèi)研究
Loreclezole (10, 25, 50 or 75 mg/kg, i.p. 60 min before measurement of seizure threshold ) results in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. Loreclezole also has the least effect on loss of muscle tone as measured by the “pull-up” test.
| Animal Model: | Adult male Lister Hooded rats. |
| Dosage: | 10, 25, 50 or 75 mg/kg. |
| Administration: | IP, 60 min before measurement of seizure threshold. |
| Result: | Resulted in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. |