2225940-48-5
中文名稱
Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
英文名稱
Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
CAS
2225940-48-5
分子式
C18H19N3O6
分子量
373.36
MOL 文件
2225940-48-5.mol
2225940-48-5 結(jié)構(gòu)式
基本信息
中文別名
泊馬度胺 4'-烷基C4-酸化合物POMALIDOMIDE-C4-COOH
5-[[2-(2,6-二氧基-3-哌啶基)-2,3-二氫-1,3-二氧基-1H-異吲哚-4-基]氨基]戊酸
英文別名
JUN 40485Pomalidomide-C4-COOH
5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)pentanoic acid
Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
所屬類別
生物化工：抑制劑物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO|37.34|100|DMF|37.34|100|
形態(tài)Solid
顏色Light yellow to yellow
應(yīng)用領(lǐng)域
用途一
Pomalidomide-C4-acid, also known as Pomalidomide 4'-alkylC4-acid and JUN 40485, is a Pomalidomide-based cereblon ligand with a linker, which is a useful precursor for synthesis of PROTAC degraders. Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to tackle disease-causing proteins that have historically been highly challenging to target with conventional small molecules. PROTAC degraders are usually heterobifunctional small molecules consisting of two ligands joined by a linker: one ligand recruits and binds a protein of interest (POI) while the other recruits and binds an E3 ubiquitin ligase. Simultaneous binding of the POI and ligase by the PROTAC induces ubiquitylation of the POI and its subsequent degradation by the ubiquitin–proteasome system (UPS), after which the PROTAC is recycled to target another copy of the POI.