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2222-07-3

中文名稱 葫蘆素 I
英文名稱 CUCURBITACIN I
CAS 2222-07-3
分子式 C30H42O7
分子量 514.65
MOL 文件 2222-07-3.mol
更新日期 2024/12/20 18:42:32
2222-07-3 結(jié)構(gòu)式 2222-07-3 結(jié)構(gòu)式

基本信息

中文別名
葫蘆素
葫蘆素 I
葫蘆素I(甄準(zhǔn)不供應(yīng))
英文別名
JSI-124
Ibamarin
ELATERIN B
NSC 521777
ELATERICIN B
CUCURBITACIN I
5-tetrahydroxy-
cucurbitacine(i)
CUCURBITACIN I(SH)
CUCURBITACIN I hplc
所屬類別
分析化學(xué):藥典標(biāo)準(zhǔn)品和雜質(zhì)標(biāo)準(zhǔn)品

物理化學(xué)性質(zhì)

熔點(diǎn)148-150°C
沸點(diǎn)698.3±55.0 °C(Predicted)
密度1.26±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C
溶解度≥22.45 mg/mL in DMSO; insoluble in EtOH; ≥51.2 mg/mL in H2O with ultrasonic
酸度系數(shù)(pKa)8.51±0.70(Predicted)
形態(tài)固體
顏色白色至灰白色
LogP2.330 (est)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS06
警示詞危險(xiǎn)
危險(xiǎn)性描述H301
危險(xiǎn)品標(biāo)志Xi,T+
危險(xiǎn)類別碼25-28
安全說明1-22-45-36/37-28
危險(xiǎn)品運(yùn)輸編號(hào)UN 2811 6.1/PG 1
危險(xiǎn)品運(yùn)輸編號(hào)UN 2811 6.1/PG 1
WGK Germany3
RTECS號(hào)RC6200000
毒性LD50 oral in mouse: 5mg/kg
葫蘆素 I價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-N1405葫蘆素 I
Cucurbitacin I
2222-07-31mg1480元
2024/11/08HY-N1405葫蘆素 I
Cucurbitacin I
2222-07-35mg3780元
2024/11/08HY-N1405葫蘆素 I
Cucurbitacin I
2222-07-310mM * 1mLin DMSO4280元

常見問題列表

生物活性
Cucurbitacin I 是 JAK2/STAT3 的天然選擇性抑制劑,并具有有效的抗腫瘤活性。
靶點(diǎn)

JAK2

STAT3

體外研究

Exposure of the COLO205 cells to Cucurbitacin I significantly decreases cell viability. The anticancer activity of Cucurbitacin I is accomplished by downregulating p-STAT3 and MMP-9 expression. PE-induced cell enlargement and upregulation of ANF and β-MHC are significantly suppressed by pretreatment of the cardiomyocytes with Cucurbitacin I. Notably, Cucurbitacin I also impaires connective tissue growth factor (CTGF) and MAPK signaling, pro-hypertrophic factors, as well as TGF-β/Smad signaling, the important contributing factors to fibrosis. Incubation of the Seax cell line with the Jak/Stat3 inhibitor Cucurbitacin I result in a time- and concentration-dependent decrease of P-Stat3 and Stat3. In freshly isolated Sz cells (n=3), Cucurbitacin I induces a concentration-dependent decrease in Stat3 expression whereas P-Stat3 is undetectable. Finally, incubation of freshly isolated Sz cells (n=4) with 30 μM Cucurbitacin I for 6 hours induces apoptosis in the large majority (73-91%) of tumor cells.

體內(nèi)研究

No major side effects are noted throughout the study. It is shown that average tumor volumes at the end of the study are as follows: control, 616 mm 3 (±130); CQ, 580 mm 3 (±107); Cucurbitacin I, 346mm 3 (±79); and combination, 220mm 3 (±62). The differences in tumor volume between the Cucurbitacin I and control, combination and control, and combination and Cucurbitacin I arms are significant. Furthermore, combination-treated tumors exhibit a significantly lower average tumor weight at study termination than the control. Moreover, there was no effect on the body weights of mice.

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