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221529-58-4

中文名稱 RO1138452
英文名稱 4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE
CAS 221529-58-4
分子式 C19H23N3O
分子量 309.41
MOL 文件 221529-58-4.mol
更新日期 2024/12/15 19:35:15
221529-58-4 結(jié)構(gòu)式 221529-58-4 結(jié)構(gòu)式

基本信息

中文別名
化合物RO1138452
RO1138452游離態(tài)
N-[4-(4-異丙氧基芐基)苯基]-4,5-二氫-1H-咪唑-2-胺
英文別名
CAY10441
RO1138452
CAY10441 RO1138452
RO1138452 CAY10441
CAY10441 Exclusive
RO 1138452
RO-1138452
RO1138452
CAY 10441
CAY-10441
CAY10441
N-(4-(4-Isopropoxybenzyl)phenyl)-4,5-dihydro-1H-imidazol-2-amine
4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE
1H-Imidazol-2-amine, 4,5-dihydro-N-[4-[[4-(1-methylethoxy)phenyl]methyl]phenyl]-
所屬類別
生物:小分子化合物

物理化學(xué)性質(zhì)

沸點(diǎn)449.7±47.0 °C(Predicted)
密度1.13±0.1 g/cm3(Predicted)
儲(chǔ)存條件Keep in dark place,Inert atmosphere,2-8°C
溶解度DMF: 30 mg/ml; DMF:PBS (pH 7.2)(1:10): 0.05 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml
酸度系數(shù)(pKa)9.94±0.33(Predicted)
形態(tài)A crystalline solid
顏色Light yellow to brown

常見問(wèn)題列表

生物活性
RO1138452 是一種有效的選擇性前列環(huán)素 IP (prostacyclin) 受體拮抗劑。RO1138452 對(duì) IP 受體具有高的親和力。在人血小板中,pKi 值為 9.3±0.1; 在重組 IP 受體系統(tǒng)中,pKi 值為 8.7±0.06。
靶點(diǎn)
TargetValue
PGI2
(in human platelets)
9.3(pKi)
PGI2
(in a recombinant IP receptor system)
8.7(pKi)
體外研究

RO1138452 is IP receptor antagonist. The pIC 50 values of RO1138452 in attenuating cAMP accumulation is 7.0±0.07. Functional antagonism of RO1138452 is studied by measuring inhibition of carbaprostacyclin-induced cAMP accumulation in CHO-K1 cells stably expressing the human IP receptor. The antagonist affinity (pK i ) of RO1138452 is 9.0±0.06. Selectivity profiles for RO1138452 are determined via a panel of receptor binding and enzyme assays. RO1138452 displays affinity at imidazoline 2 (I 2 ) (8.3) and platelet activating factor (PAF) (7.9) receptors. RO1138452 (10 pM-10 μM) added to cells concurrently with a fixed concentration of Taprostene (1 μM) prevents, in a concentration-dependent manner, the inhibition of CXCL9 and CXCL10 release, with p[A] 50 (molar) values of -8.73±0.11 and -8.47±0.16 (p>0.05), respectively.

體內(nèi)研究

RO1138452 is a potent and selective antagonist for both human and rat IP receptors and that is possesses analgesic and anti-inflammatory potential. RO1138452 (1-10?mg/kg, i.v.) significantly reduces acetic acid-induced abdominal constrictions. RO1138452 (3-100?mg/kg, p.o.) significantly reduces carrageenan-induced mechanical hyperalgesia and edema formation. One?hour after administration of RO1138452 (5?mg/kg, i.v.) to rats, the total plasma concentration is 0.189 ?μg/mL, whereas the free plasma concentrations is calculated to be 0.009?μg/mL (28 nM).

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