220757-88-0
中文名稱
TCFA15
英文名稱
2-Cyclohexen-1-one, 3-(15-hydroxypentadecyl)-2,4,4-trimethyl-
CAS
220757-88-0
分子式
C24H44O2
分子量
364.61
MOL 文件
220757-88-0.mol
220757-88-0 結(jié)構(gòu)式
基本信息
中文別名
化合物 T13917 英文別名
TCFA153-(15-Hydroxypentadecyl)-2,4,4-trimethylcyclohex-2-enone
2-Cyclohexen-1-one, 3-(15-hydroxypentadecyl)-2,4,4-trimethyl-
物理化學(xué)性質(zhì)
沸點(diǎn)478.1±24.0 °C(Predicted)
密度0.910±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO : 130 mg/mL (356.56 mM);Water : < 0.1 mg/mL (insoluble)
酸度系數(shù)(pKa)15.20±0.10(Predicted)
形態(tài)Oil
顏色Light yellow to yellow
常見問題列表
生物活性
tCFA15 為一種三甲基環(huán)己烯長鏈脂肪醇，側(cè)鏈含有 15 個(gè)碳原子，能夠促進(jìn)神經(jīng)細(xì)胞的分化，具有調(diào)控 Notch 信號通路的潛力。靶點(diǎn)
Notch1
體外研究
tCFA15 (10 nM-1 μM) dose-dependently affects the differentiation of neural stem cell-derived neurospheres by promoting neurons at the expense of astrocytes, and such effect is via Notch1. tCFA15 (1 μM) specifically decreases the level of Notch1 mRNA in spheres, and such an effect is also observed in decreases Notch1 expression in neuronal and glial cell cultures. tCFA15 stimulates arginine vasopressin secretion in nerve terminals of the neurohypophysis.