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218791-21-0

中文名稱 218791-21-0
英文名稱 IMISOPASEM MANGANESE
CAS 218791-21-0
分子式 C21H35N5.Cl2Mn
分子量 483.387
MOL 文件 218791-21-0.mol
更新日期 2024/12/03 15:40:36
218791-21-0 結(jié)構(gòu)式 218791-21-0 結(jié)構(gòu)式

基本信息

中文別名
伊米帕錳
英文別名
CG4419
CG 4419
M-40403
SC72325
CG-4419
SC-72325
SC 72325
IMISOPASEM MANGANESE
Imisopasem manganese(m40403)
M40403
M 40403
M-40403
CG4419
CG 4419
CG-4419
SC72325
SC-72325
SC 72325
IMISOPASEM MANGANESE
所屬類別
生物化工:激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

儲(chǔ)存條件Inert atmosphere,2-8°C
溶解度DMSO:5.0(Max Conc. mg/mL);10.34(Max Conc. mM)
DMF:3.0(Max Conc. mg/mL);6.21(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);41.38(Max Conc. mM)
PBS (pH 7.2):3.0(Max Conc. mg/mL);6.21(Max Conc. mM)
Water:16.0(Max Conc. mg/mL);33.1(Max Conc. mM)
形態(tài)結(jié)晶固體
顏色White to off-white

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
防范說(shuō)明P261-P305+P351+P338
218791-21-0價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-13336218791-21-0
Imisopasem manganese
218791-21-02mg990元
2024/11/08HY-13336218791-21-0
Imisopasem manganese
218791-21-05mg1700元
2024/11/08HY-13336218791-21-0
Imisopasem manganese
218791-21-010mM * 1mLin Water1793元

常見(jiàn)問(wèn)題列表

生物活性
Imisopasem manganese (M40403)是穩(wěn)定的MnSOD的非肽基模擬物。
體外研究

M40403 is a small molecule, synthetic manganese containing superoxide dismutase mimetic (SODm) that removes superoxide anions without interfering with other reactive species known to be involved in inflammatory responses (e.g. nitric oxide, NO and peroxynitrite, ONOO-).

體內(nèi)研究

M40403 is a small-molecule superoxide dismutase mimetic that has shown efficacy in animal model disease states in which superoxide anions are thought to play a key role. M40403 inhibits the inflammatory response following the intrapleural injection of carrageenan in rats. All parameters of inflammation are attenuated by M40403 except for NOx, PGE2 and IL-10 which remains unaltered. Decreased apoptosis of the large and particularly the small bowel and marked recovery of both lymphoid and hematopoietic tissues occurs in the M40403 pre-treated mice. M40403 is effective in reducing TBI-induced tissue destruction and has potential as a new radioprotective agent.

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