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218137-86-1

中文名稱(chēng) 218137-86-1
英文名稱(chēng) 3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE
CAS 218137-86-1
分子式 C14H22O4
分子量 254.32
MOL 文件 218137-86-1.mol
更新日期 2024/07/08 16:38:21
218137-86-1 結(jié)構(gòu)式 218137-86-1 結(jié)構(gòu)式

基本信息

中文別名
化合物C75
化合物 T10657
英文別名
C75
FAS inhibitor C75 (C-75
C75 >=98% (HPLC), powder
3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE
TRANS-4-CARBOXY-5-OCTYL-3-METHYLENEBUTYROLACTONE
3-Furancarboxylic acid, tetrahydro-4-methylene-2-octyl-5-oxo-
C75(4-Methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylicacid)
TRANS-TETRAHYDRO-3-METHYLENE-2-OXO-5-N-OCTYL-4-FURANCARBOXYLIC ACID
所屬類(lèi)別
生物化工:激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

沸點(diǎn)432.1±45.0 °C(Predicted)
密度1.08±0.1 g/cm3(Predicted)
儲(chǔ)存條件2-8°C
溶解度DMSO: 18 mg/mL
酸度系數(shù)(pKa)3.08±0.40(Predicted)
形態(tài)solid
顏色off-white

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
WGK Germany3
218137-86-1價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2024/11/08HY-12364218137-86-1
C75
218137-86-12 mg866元
2024/11/08HY-12364218137-86-1
C75
218137-86-15mg1100元
2024/11/08HY-12364218137-86-1
C75
218137-86-110mM * 1mLin DMSO1211元

常見(jiàn)問(wèn)題列表

生物活性
C75 是合成的脂肪酸合成酶 (FASN) 抑制劑。C75 抑制前列腺癌細(xì)胞 PC3 的 IC50 值為 35 μM。C75 是有效的 CPT1A 激活劑。
靶點(diǎn)

IC50: 35 μM (PC3 cell)

體外研究

C75 inhibits PC3 cell growht with an IC 50 of 35 μM at 24 h. C75 (10-50 μM) also reduces the growth of LNCaP spheroids in a concentration-dependent manner with an IC 50 of 50 μM. (-)-C75 inhibits FAS activity and has a cytotoxic effect on tumor cell lines, without affecting food consumption. (+)-C75 inhibits CPT1 and its administration produces anorexia, suggesting that central inhibition of CPT1 is essential for the anorectic effect of C75. The differential activity of C75 enantiomers may lead to the development of potential new specific drugs for cancer and obesity.

體內(nèi)研究

C75 blocks fasting-induced c-Fos expression in the arcuate nucleus (Arc), lateral hypothalamic area (LHA), and paraventricular nucleus (PVN) 10–24 h after i.p. injection. Intraperitoneal administration of C75 at 30 mg/kg body weight inhibits food intake of mice by ≥95% within 2 h after i.p. injection. C75-treated DIO mice has a 50% greater weight loss, and a 32.9% increased production of energy because of fatty acid oxidation. C75 treatment of rodent adipocytes and hepatocytes and human breast cancer cells increases fatty acid oxidation and ATP levels by increasing CPT-1 activity, even in the presence of elevated concentrations of malonyl-CoA.

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