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217082-60-5

中文名稱 人牛吡啶APELIN-13
英文名稱 PYR-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH
CAS 217082-60-5
分子式 C69H108N22O16S
分子量 1533.8
MOL 文件 217082-60-5.mol
更新日期 2024/12/23 10:30:30
217082-60-5 結(jié)構(gòu)式 217082-60-5 結(jié)構(gòu)式

基本信息

中文別名
人牛吡啶APELIN-13
[PYR1]-愛帕琳肽-13
[PYR1]-愛帕琳肽-13, >98%
人,牛(GLP1)-APELIN-13肽
英文別名
Pyr-apelin-13
[PYR1]-APELIN-13
(Glp1)-Apelin-13
[pGlu1]-Apelin-13
PYR-RPRLSHKGPMPF-OH
[PE]APELIN-13, HUMAN, BOVINE
(GLP1)-APELIN-13, HUMAN, BOVINE
(PYR1)-APELIN-13 (HUMAN, BOVINE)
[PGLU1]APELIN (24-36), HUMAN, BOVINE
(PYR1)-APELIN-13 (HUMAN, BOVINE, MOUSE, RAT)
所屬類別
生物化工:多肽

物理化學(xué)性質(zhì)

密度1.51±0.1 g/cm3(Predicted)
儲存條件Keep in dark place,Sealed in dry,Store in freezer, under -20°C
酸度系數(shù)(pKa)3.56±0.10(Predicted)
形態(tài)粉末
顏色White to off-white
水溶解性Soluble to 1 mg/ml in sterile water
序列Pyr-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302-H315-H319-H335

常見問題列表

生物活性
[Pyr1]-Apelin-13 是一種高效的,選擇性的內(nèi)源性 apelin 受體激動劑。
體外研究

[Pyr1]-apelin-13 encapsulation in lipoPEG particles (lipoPEG-PA13) results in sustained and extended drug release under physiological conditions.

體內(nèi)研究

[Pyr1]-apelin-13 nanocarriers in a mouse model of pressure-overload induced heart failure demonstrate a sustainable long-term effect of [Pyr1]-apelin-13 in preventing cardiac dysfunction. [Pyr1] apelin-13 (1, 5 μg) improves locomotor activity and reduces pain symptoms, cavity size and caspase-3 levels in rats. [Pyr1] apelin-13 (1, 5 μg) significantly increases thermal paw withdrawal latency. [Pyr1] apelin-13 in 5 μg dose also produces significant attenuation in paw withdrawal threshold compared to SCI animals from the second week post SCI.

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