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2170679-42-0

中文名稱 DBRD9-A
英文名稱 Acetamide, 2-[[[4-(1,2-dihydro-2-methyl-1-oxo-2,7-naphthyridin-4-yl)-2,6-dimethoxyphenyl]methyl]methylamino]-N-[8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]octyl]-
CAS 2170679-42-0
分子式 C42H49N7O8
分子量 779.9
MOL 文件 2170679-42-0.mol
2170679-42-0 結(jié)構(gòu)式 2170679-42-0 結(jié)構(gòu)式

基本信息

英文別名
dBRD9-A
Acetamide, 2-[[[4-(1,2-dihydro-2-methyl-1-oxo-2,7-naphthyridin-4-yl)-2,6-dimethoxyphenyl]methyl]methylamino]-N-[8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]octyl]-

物理化學(xué)性質(zhì)

儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO|77.99|100|ethanol|7.8|10|

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictogramsGHS hazard pictograms
GHS08,GHS06
警示詞危險(xiǎn)
危險(xiǎn)性描述H360-H301

應(yīng)用領(lǐng)域

用途一
dBRD9-A is a potent BRD9 degrader that selectively binds BRD9 and elicits near complete degradation of BRD9 at nanomolar concentrations. It was shown to inhibit the growth of synovial sarcoma cells in vitro and tumor progression in a synovial sarcoma xenograft mouse model.
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