216167-82-7
基本信息
AGZ-1067
SUCCINOBUCOL
SUCCINOBUCOL, >98%
Probucol Monosuccinate
Succinobucol(AGI 1067)
Probucol monosuccinate, >98%
AGZ1067. Probucol monosuccinae
AGI-1067
PROBUCOL MONOSUCCINATE
SUCCINOBUCOL
AGI-1067
AGZ-1067
AGI1067
AGZ1067. PROBUCOL MONOSUCCINAE
物理化學性質
報價日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
2024/11/08 | HY-14937 | AGI 1067 Succinobucol | 216167-82-7 | 5mg | 600元 |
2024/11/08 | HY-14937 | AGI 1067 Succinobucol | 216167-82-7 | 10mM * 1mLin DMSO | 814元 |
2024/11/08 | HY-14937 | AGI 1067 Succinobucol | 216167-82-7 | 10mg | 1000元 |
常見問題列表
Succinobucol (10, 50, 100 μM) causes a dose-dependent reduction in collagen-induced platelet aggregation in rabbit whole blood. Succinobucol also causes a significant reduction in whole blood aggregation in response to ADP. Succinobucol (10, 100 μM) significantly lowers the relaxation to X/XO. Succinobucol significantly prevents 3-NP-induced loss of SH-SY5Y cell viability, generation of reactive oxygen species, and decrease of ΔΨm. Succinobucol does not protect against 3-NP-induced inhibition of mitochondrial complex II activity, pointing to the mitigation of secondary events resultant from mitochondrial complex II inhibition. Succinobucol significantly increases (50 %) the levels of GSH in SH-SY5Y cells, which is paralleled by significant increases in glutamate cysteine ligase messenger RNA (mRNA) expression and activity. Succinobucol effectively exhibits superior inhibitory effects on cell migration and invasion activities, VCAM-1 expression and cell-cell binding of RAW 264.7 to 4T1 cells. Succinobucol also shows inhibitory effect on VCAM-1 expression in 4T1 cells and cell-cell binding of RAW 264.7 to 4T1 cancer cells.
Succinobucol (50, 100, and 150 mg/kg, i.v.) has no significant effect on either heart rate or MAP, but the blood removed 15 minutes after the final injection of succinobucol shows significantly less aggregation in response to collagen at both 5 μg/mL and 20 μg/mL in rats. Succinobucol (40 mg/kg) by tail injection significantly reduces the average number of metastatic nodules in lung metastatic breast cancer mice.