2158266-58-9
2158266-58-9 結(jié)構(gòu)式
基本信息
中文別名
化合物 T15399 英文別名
GNE-2072-Pyridinecarboxamide, 5-[8-[5-acetyl-4,5,6,7-tetrahydro-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-3-isoquinolinyl]-N-methyl-
物理化學(xué)性質(zhì)
沸點(diǎn)812.8±65.0 °C(Predicted)
密度1.38±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 200 mg/mL (391.70 mM)
酸度系數(shù)(pKa)13.75±0.46(Predicted)
形態(tài)Solid
顏色White to off-white
應(yīng)用領(lǐng)域
用途一
GNE-207 is a novel, potent, and orally bioavailable inhibitor of the bromodomain of CBP. GNE-207 has excellent CBP potency (CBP IC50?=?1?nM, MYC EC50?=?18?nM), and it exhibits a good pharmacokinetic profile.