2102672-22-8
中文名稱(chēng)
DK419
英文名稱(chēng)
DK419
CAS
2102672-22-8
分子式
C16H8ClF6N3O
分子量
407.7
MOL 文件
2102672-22-8.mol
2102672-22-8 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)417.7±45.0 °C(Predicted)
密度1.611±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 83.33 mg/mL (204.39 mM)
酸度系數(shù)(pKa)7.22±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
應(yīng)用領(lǐng)域
用途一
DK419 is a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth. DK419 inhibited Wnt/β-catenin signaling, altered cellular oxygen consumption rate and induced production of pAMPK. DK419 inhibited the growth of CRC tumor cells in vitro, had good plasma exposure when dosed orally, and inhibited the growth of patient derived CRC240 tumor explants in mice dosed orally.