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2098799-80-3

中文名稱 (2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-6,9,12-trioxa-3-azapentadec-14-yn-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
英文名稱 (2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-6,9,12-trioxa-3-azapentadec-14-yn-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS 2098799-80-3
分子式 C31H42N4O7S
分子量 614.75
MOL 文件 2098799-80-3.mol
更新日期 2024/12/12 14:57:19
2098799-80-3 結構式 2098799-80-3 結構式

基本信息

中文別名
VH 032 酰胺-PEG2-炔
英文別名
VH 032-linker 6
L-Prolinamide, 3-methyl-N-[2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]acetyl]-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
(2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-6,9,12-trioxa-3-azapentadec-14-yn-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

物理化學性質

沸點870.9±65.0 °C(Predicted)
密度1.237±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)13.54±0.46(Predicted)
形態(tài)Solid
顏色Light yellow to yellow

應用領域

用途一
VH 032 Linker 6 is a derivative of the proteolysis-targeting chimera technology (PROTAC) for PROTAC research and development; by incorporating an E3 ligase ligand and a PEG2 linker with terminal alkyne, it is ready for conjugation to a target protein ligand
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