209394-27-4
209394-27-4 結(jié)構(gòu)式
基本信息
Ladostigil (TV-3,326)
LHXOCOHMBFOVJS-OAHLLOKOSA-N
Carbamic acid, N-ethyl-N-methyl-, (3R)-2,3-dihydro-3-(2-propyn-1-ylamino)-1H-inden-5-yl ester
常見問題列表
|
MAO-B 37.1 μM (IC 50 ) |
AChE 31.8 μM (IC 50 ) |
Ladostigil (1-10 μM) exerts neuroprotective activities, including a prevention of the fall of the mitochondrial membrane potential (ψ), attenuation of apoptotic cascades and an inhibition of ROS production induced by OS insults.
Ladostigil (1-10 μM) has a significant neuroprotective activity, including inhibition of caspase-3 activation, induction of Bcl-2 and reduction of Bad and Bax gene and protein expression in human neuroblastoma SK-N-SH cells.
Ladostigil (17 mg/kg; p.o. daily for 6 weeks) abolishes their hyperanxiety and depressive-like behaviour in the elevated plus maze (EPM) and forced swim tests (FST) tests in adulthood from puberty to prenatally-stressed rats.
Ladostigil (50 μmol/kg; single p.o.) restores the loss of episodic memory in the object recognition test in rats.
| Animal Model: | Pathogen-free (SPF) Sprague-Dawley rats |
| Dosage: | 17 mg/kg |
| Administration: | P.o. (added to the drinking water) daily for 6 weeks |
| Result: |
Inhibited brain MAO-A and B by more than 60%.
Reduced hyperanxiety of male and female prenatally stressed (PS) rats in the EPM and depressive-like behaviour in the FST. |