2070015-13-1
中文名稱
ML241 (hydrochloride)
英文名稱
ML241 (hydrochloride)
CAS
2070015-13-1
分子式
C23H25ClN4O
分子量
408.93
MOL 文件
2070015-13-1.mol
更新日期
2024/11/15 18:20:30
2070015-13-1 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
溶解度≥40.9 mg/mL in DMSO; insoluble in H2O; ≥48.7 mg/mL in EtOH
形態(tài)固體
顏色White to off-white
ML241 (hydrochloride)價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-19797A | ML241 (hydrochloride) ML241 hydrochloride | 2070015-13-1 | 5mg | 600元 |
| 2024/11/08 | HY-19797A | ML241 (hydrochloride) ML241 hydrochloride | 2070015-13-1 | 10mM * 1mLin DMSO | 880元 |
| 2024/11/08 | HY-19797A | ML241 (hydrochloride) ML241 hydrochloride | 2070015-13-1 | 10mg | 960元 |
常見問題列表
生物活性
ML241 hydrochloride 是一種 p97 的有效選擇性抑制劑，對(duì) p97 ATPase 和 UbG76V–GFP 的IC50值分別為0.11 μM和3.5 μM。靶點(diǎn)
| Target | Value |
|
p97 ATPase
(Cell-free assay) | 0.11 μM |
|
Ub
(Cell-free assay) | 3.5 μM |
體外研究
ML241 hydrochloride is a potent p97 inhibitor, inhibiting p97 ATPase with IC 50 values of 100 nM. ML241 inhibits p97 competitively with respect to ATP with a K i values of 0.35 μM. ML241 (20 μM) shows no obvious inhibition of the appr 170 kinases tested. ML241 stabilizes Ub G76V -GFP with IC 50 of 3.5 μM. ML241 is cytotoxic to HCT15 and SW403 cells, with GI 50 s of 53 and 33 μM after treatment for 24 h, and 13 and 12 μM after treatment for 72 h, respectively.