204992-09-6
中文名稱
NETAMIFTIDE
英文名稱
NETAMIFTIDE
CAS
204992-09-6
分子式
C37H45F7N10O10
分子量
808.79
MOL 文件
204992-09-6.mol
204992-09-6 結(jié)構(gòu)式
基本信息
中文別名
NEMIFITIDE DITFA 英文別名
NETAMIFTIDEINN 00835 diTFA
Nemifitide diTFA
Bis(trifluoroacetate)
Netamiftide ditriflutate
(2S)-N-[(1S)-1-[[(1S)-1-[[(2S)-2-amino-3-(4-fluorophenyl)propanoyl]carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoylmethylcarbamoyl]-4-(diaminomethylideneamino)butyl]-4-hydroxy-pyrrolidine-2-carboxamide
物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C儲(chǔ)存
形態(tài)Solid
顏色White to off-white
水溶解性Water: 250 mg/mL (270.91 mM)
NETAMIFTIDE價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-105077A | NETAMIFTIDE Nemifitide diTFA | 204992-09-6 | 5mg | 2500元 |
| 2024/11/08 | HY-105077A | NETAMIFTIDE Nemifitide diTFA | 204992-09-6 | 10mg | 4500元 |
| 2024/11/08 | HY-105077A | NETAMIFTIDE Nemifitide diTFA | 204992-09-6 | 10mM * 1mLin Water | 4570元 |
常見問題列表
生物活性
Nemifitide diTFA (INN 00835 diTFA) 是一種合成的五肽抗抑郁藥，具有迅速起效的潛力。Nemifitide diTFA 是黑色素細(xì)胞抑制因子 (MIF) 的肽類似物。Nemifitide diTFA 可以透過血腦屏障。體外研究
Nemifitide diTFA (INN 00835 diTFA) and its active metabolite (M1) bind at micromolar concentrations to several receptors including the 5-HT 2A , 5-HT 2C , melanocortin MC4, MC5 and bombesin.
體內(nèi)研究
Nemifitide diTFA (INN 00835 diTFA; 0.3 mg/kg; IP; daily; for 14 days) significantly increases swimming in the FSL rats after just 5 days of treatment and has long-lasting effect.
Nemifitide diTFA (0.0125-15.0 mg/kg) significantly increases swimming in the FSL rats at both low (0.025-0.3 mg/kg) and high (3.0-15.0 mg/kg) doses but not at intermediate (0.4-2.4 mg/kg) doses.
| Animal Model: | Male Flinders Sensitive Line (FSL) rat weighing 280-320 g |
| Dosage: | 0.3 mg/kg |
| Administration: | IP; daily; for 14 days |
| Result: | Significantly increased swimming in the FSL rats after just 5 days of treatment and had long-lasting effect. |