202057-76-9
202057-76-9 結(jié)構(gòu)式
基本信息
中文別名
化合物 T11941 英文別名
FK778manitimus
2-Hepten-6-ynamide, 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-, (Z)-
2-Hepten-6-ynamide, 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-, (2Z)-
物理化學(xué)性質(zhì)
沸點(diǎn)489.4±45.0 °C(Predicted)
密度1.382±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 250 mg/mL (811.00 mM)
酸度系數(shù)(pKa)5.23±0.50(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
常見(jiàn)問(wèn)題列表
生物活性
Manitimus 是一種 dehydroorotate dehydrogenase 的抑制劑，同時(shí)為有效的免疫抑制藥。體內(nèi)研究
In the Manitimus-treated rats, there is a dose-related, differential effect: mean survival is 15.7 days in group 4 (Manitimus 5 mg/kg), 19.1 days in group 5 (Manitimus 10 mg/kg) and 25.4 days in group 6 (Manitimus 20 mg/kg). Manitimus (15 mg/kg, p.o.) results in a significant decrease in neointimal area and percentage of stenosis versus the control rats, and diminishes the effect that CMV infection results in a significant increase in intimal and medial cross-sectional area and medial wall thickness of the vein grafts.