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199655-36-2

中文名稱 CP 465022 HYDROCHLORIDE
英文名稱 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride
CAS 199655-36-2
分子式 C26H24ClFN4O
分子量 462.95
MOL 文件 199655-36-2.mol
199655-36-2 結(jié)構(gòu)式 199655-36-2 結(jié)構(gòu)式

基本信息

中文別名
3-(2-氯苯基)-2-[2-[6-[(二乙基氨基)甲基]-2-吡啶基]乙烯基]-6-氟-4(3H)喹唑啉酮
英文別名
CP465022HCl
CP465022
CP-465022
CP 465022 hydrochloride
3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinone
4(3H)-Quinazolinone, 3-(2-chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-
3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride
CP 465022 hydrochloride,3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride
所屬類別
生物化工:激動劑抑制劑

物理化學(xué)性質(zhì)

沸點585.0±60.0 °C(Predicted)
密度1.23±0.1 g/cm3(Predicted)
儲存條件Desiccate at RT
溶解度insoluble in H2O; <49.94mg/ml in DMSO
酸度系數(shù)(pKa)8.51±0.25(Predicted)
形態(tài)固體
顏色黃色
CP 465022 HYDROCHLORIDE價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2023/03/20HY-18663BCP 465022 HYDROCHLORIDE
CP-465022 hydrochloride
199655-36-25 mg6900元
2023/03/20HY-18663BCP 465022 HYDROCHLORIDE
CP-465022 hydrochloride
199655-36-210 mg11000元

常見問題列表

生物活性
CP-465022 hydrochloride 是一種強效的、選擇性的、非競爭性的 AMPA受體 拮抗劑,具有抗驚厥活性。CP-465022 對 Kainate 誘導(dǎo)反應(yīng)具有抑制作用,IC50 為 25 nM。CP-465022 是研究 AMPA 受體在生理和病理方面研究的有效工具。
靶點

IC50: 25 nM (rat cortical neurons)

體外研究

CP-465022 (0.0001 μM-10 μM) inhibits kainate-induced response in relatively slow manner and dependents on compound concentration, exhibiting a calculated IC 50 of 25 nM and essentially complete inhibition at 3.2 μM. CP-465022 1 μM for 10 min has little effect on peak NMDA-induced currents but reduces current measured at 8 s during NMDA application by 26%.CP-465,022 at 10 μM inhibits peak NMDA-induced currents in cortical neurons by 36% and currents measured at 8 s by 70% d in primary cultures of cortical and cerebellar granule neurons. CP-465022 1 μM for 10 min inhibits peak NMDA currents in cultured rat cerebellar granule neurons with mean inhibition of 19% and NMDA currents measured at 8 s by 45%, similar to what is observed in the cortical neurons.CP-465022 (100 nM -10 μM) has inhibitory effects on Kainate-induced whole-cell currents in voltage-clamped rat hippocampal, 100 nM CP465,022 inhibits kainate currents developed over the course of 200s, 500 nM and 1 μM CP-465,022 nearly complete inhibits this time frame (99.3%).

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