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1964516-64-0

英文名稱 4-Thiazolecarboxylic acid, 2-[4-[[4-(aminosulfonyl)-3-fluorophenyl]methyl]-5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(5-methyl-2-thienyl)ethynyl]phenyl]-1H-pyrazol-1-yl]-
CAS 1964516-64-0
分子式 C31H24F2N4O4S3
分子量 650.74
MOL 文件 1964516-64-0.mol
1964516-64-0 結(jié)構(gòu)式 1964516-64-0 結(jié)構(gòu)式

基本信息

英文別名
NCI-006
4-Thiazolecarboxylic acid, 2-[4-[[4-(aminosulfonyl)-3-fluorophenyl]methyl]-5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(5-methyl-2-thienyl)ethynyl]phenyl]-1H-pyrazol-1-yl]-

應(yīng)用領(lǐng)域

用途一
NCI-006 is a potent new inhibitor of lactate dehydrogenase (LDH) that disrupts tumor growth in mice. LDH inhibition slows tumor growth but rapidly redirects pyruvate to support mitochondrial metabolism. Inhibiting both mitochondrial complex 1 and LDH suppresses metabolic plasticity of glycolytic tumors in vivo, significantly prolonging tumor growth inhibition.
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