195513-96-3
195513-96-3 結構式
物理化學性質
沸點656.9±65.0 °C(Predicted)
密度1.161±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2)(1:3): .2 mg/ml
酸度系數(shù)(pKa)4.14±0.10(Predicted)
形態(tài)Oil
顏色Light yellow to yellow
常見問題列表
生物活性
SLF 是 FK506 結合蛋白 (FKBP) 的合成配體，對 FKBP51 的親和力為 3.1 μM，對 FKBP12 的 IC50 為 2.6 μM，可用于合成 PROTAC 分子。體外研究
Three scout fragments-KB02, KB03, and KB05 are fused, which cover two different electrophile groups (chloroacetamide and acrylamide) and display broad cysteine reactivity in the human proteome-to the SLF ligand that binds tightly and selectively to FKBP12, a cytosolic prolyl isomerase that has been frequently used to study ligand-induced protein degradation.