193620-69-8
中文名稱
3-(雙(4-甲氧基苯基)亞甲基)吲哚啉-2-酮
英文名稱
TAS-301
CAS
193620-69-8
分子式
C23H19NO3
分子量
357.4
MOL 文件
193620-69-8.mol
更新日期
2024/12/15 19:35:18
193620-69-8 結(jié)構(gòu)式
基本信息
中文別名
TAS-301游離態(tài)3-[二(4-甲氧基苯基)亞甲基]-1,3-二氫-2H-吲哚-2-酮
英文別名
CS-1543TAS 301.TAS301
TAS-301
TAS 301.TAS301
3-[bis(4-methoxyphenyl)methylidene]-1H-indol-2-one
3-[Bis(4-methoxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one
2H-Indol-2-one,3-[bis(4-methoxyphenyl)methylene]-1,3-dihydro-
物理化學(xué)性質(zhì)
儲存條件Sealed in dry,Room Temperature
溶解度DMSO: 40 mg/mL
形態(tài)solid
顏色Light yellow to yellow
3-(雙(4-甲氧基苯基)亞甲基)吲哚啉-2-酮價(jià)格(試劑級)
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2024/11/08 | S6424 | 3-(雙(4-甲氧基苯基)亞甲基)吲哚啉-2-酮 TAS-301 | 193620-69-8 | 5mg | 877.31元 |
| 2023/03/20 | S6424 | 3-(雙(4-甲氧基苯基)亞甲基)吲哚啉-2-酮 TAS-301 | 193620-69-8 | 25mg | 2596.51元 |
常見問題列表
生物活性
TAS-301是平滑肌細(xì)胞遷移和增殖的抑制劑，在大鼠頸動脈球囊損傷后抑制內(nèi)膜增厚。TAS-301 可抑制PDGF誘導(dǎo)的 PKC 激活。靶點(diǎn)
| Target | Value |
|
PKC
() |
體外研究
TAS-301 (1-10 μM) concentration-dependently inhibits PKC activation and Ca 2+ influx, induced by PDGF, with 62.7% inhibition on PKC activation at 10 μM, and reduces PMA-induced AP-1, with 38% and 67.6% inhibition at 3 and 10 μM, respectively. TAS-301 (0.3-3 μM) dose-dependently reduces the migration of cells induced by growth factors (PDGF-BB, IGF-1,HB-EGF). TAS-301 (1-10 μM) also decreases bFGF-induced BrdU incorporation, especially at 3 and 10 μM.
體內(nèi)研究
TAS-301 (3-100 mg/kg, p.o.) dose-dependently reduces the neointimal thickening and I/M ratio and decreases the level of intimal cells in rats 14 days after balloon injury.