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1917306-14-9

英文名稱 2-Thiazolecarboxamide, 5-[2,3-dichloro-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-N-(2-hydroxy-2-methylpropyl)-4-[[(2R)-2-methyl-1-pyrrolidinyl]carbonyl]-
CAS 1917306-14-9
分子式 C23H23Cl2F6N3O4S
分子量 622.41
MOL 文件 1917306-14-9.mol
1917306-14-9 結(jié)構(gòu)式 1917306-14-9 結(jié)構(gòu)式

基本信息

英文別名
tert-butyl (3R
4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate
2-Thiazolecarboxamide, 5-[2,3-dichloro-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-N-(2-hydroxy-2-methylpropyl)-4-[[(2R)-2-methyl-1-pyrrolidinyl]carbonyl]-

物理化學(xué)性質(zhì)

密度1.494±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)4.85±0.46(Predicted)
形態(tài)Solid
顏色White to off-white

應(yīng)用領(lǐng)域

用途一
JNJ-61803534 is a novel potent RORγt inverse agonist, selectively inhibiting RORγt-driven transcription versus closely-related family members, RORα and RORβ, also inhibiting IL-17A production in human CD4+ T cells under Th17 differentiation conditions, but not inhibiting IFNγ production under Th1 differentiation conditions, and having neither impact on in vitro differentiation of regulatory T cells (Treg), nor on the suppressive activity of natural Tregs.
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