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1913269-12-1

中文名稱 1913269-12-1
英文名稱 KN-93 (phosphate)
CAS 1913269-12-1
分子式 C26H32ClN2O8PS
分子量 599.03
MOL 文件 1913269-12-1.mol
更新日期 2024/11/15 18:20:33
1913269-12-1 結(jié)構(gòu)式 1913269-12-1 結(jié)構(gòu)式

基本信息

英文別名
KN93 Phosphate,KN 93 Phosphate

物理化學(xué)性質(zhì)

形態(tài)Solid
顏色White to off-white

常見問題列表

生物活性
KN-93是鈣離子/鈣調(diào)蛋白依賴激酶II(CaMKII)抑制劑,能競爭性阻斷鈣調(diào)蛋白與對應(yīng)激酶的結(jié)合,Ki為370 nM。
靶點

Ki: 370 nM (CaMK-II)

體外研究

After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. KN-93 inhibits the H + , K + -ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca 2+ -independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93.

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