1911578-83-0
中文名稱(chēng)
(2S,3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-ol
英文名稱(chēng)
(2S,3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-ol
CAS
1911578-83-0
更新日期
2023/02/22 11:54:00
分子式
C24H29N6O8P
分子量
560.5
基本信息
中文別名
瑞德西韋雜質(zhì)24 英文別名
Anti-virus agent 1Remdesivir Impurity 24
GS-441524 isopropyl ester
(2S,3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-ol
物理化學(xué)性質(zhì)
密度1.55±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 200 mg/mL (356.82 mM)
酸度系數(shù)(pKa)12.00±0.70(Predicted)
形態(tài)結(jié)晶固體
顏色White to off-white
常見(jiàn)問(wèn)題列表
生物活性
Anti-virus agent 1 (compound 4i) 是 GS-5734 (HY-104077; Remdesivir) 的氨基磷酸酯前藥，具有有效的抗病毒 (antiviral) 活性。Anti-virus agent 1 用于冠狀病毒和埃博拉病毒 (EBOV) 的研究。體外研究
Anti-virus agent 1 (compound 4i) has antiviral activity for EBOV in HeLa cell (EC 50 =1845 nM), HMVEC cell (TERT-immortalized human foreskin microvascular endothelial cells; ATCC-4025; EC 50 =367 nM), human macrophages (EC 50 =297 nM). Anti-virus agent 1 has a CC 50 of 21 μM in MT4 cell (human leukemia T-cell).