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1905453-18-0

中文名稱 1905453-18-0
英文名稱 NSC232003
CAS 1905453-18-0
分子式 C6H7N3O3
分子量 169.14
MOL 文件 1905453-18-0.mol
1905453-18-0 結(jié)構(gòu)式 1905453-18-0 結(jié)構(gòu)式

基本信息

中文別名
UHRF1抑制劑(NSC232003)
英文別名
NSC232003

物理化學(xué)性質(zhì)

密度1.60±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度Water : 17 mg/mL (100.51 mM);DMSO : < 1 mg/mL (insoluble or slightly soluble)
酸度系數(shù)(pKa)9.32±0.20(Predicted)
形態(tài)Solid
顏色White to off-white
1905453-18-0價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-1032361905453-18-0
NSC232003
1905453-18-01mg790元
2024/11/08HY-1032361905453-18-0
NSC232003
1905453-18-010mM * 1mLin Water1674元
2024/11/08HY-1032361905453-18-0
NSC232003
1905453-18-05mg1850元

常見問題列表

生物活性
NSC232003 是一種高效的可滲透細(xì)胞的 UHRF1 抑制劑,可抑制 DNA 甲基化,并破壞 DNMT1/UHRF1 相互作用。
靶點(diǎn)

UHRF1

體外研究

NSC232003, a uracil derivative freely available by the NCI/DTP repository, provides a versatile lead for developing highly potent and cell-permeable UHRF1 inhibitors that will enable dissection of DNA methylation inheritance. NSC232003 is indeed an effective DNA methylation inhibitor and indicate that this particular nucleotide scaffold could provide a versatile basis for the design of potent UHRF1 inhibitors. NSC232003 is predicted to be partially deprotonated at pH 7, as the pK a of the more acidic imide nitrogen of the pyrimidine ring is a value of 7.6 in NSC232003. The DNMT1/UHRF1 interactions are significantly reduced after 4 h of incubation of U251 glioma cells with the most potent compound NSC232003, showing a 50% interaction inhibition at 15 μM as well as induction of global DNA cytosine demethylation as measured by ELISA.

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