188860-26-6
188860-26-6 結(jié)構(gòu)式
基本信息
中文別名
2'-(3,4-二甲氧基苯基)-5-(4-甲基哌嗪-1-基)-1H,1'H-2,5'-聯(lián)苯并[D]咪唑2'-(3,4-二甲氧基苯基)-5-(4-甲基-1-哌嗪基)-2,5'-雙[1H-苯并咪唑](DMA)
2'-(3,4-二甲氧基苯基)-5-(4-甲基-1-哌嗪基)-2,5'-雙[1H-苯并咪唑](DMA)
2'-(3,4-二甲氧基苯基)-5-(4-甲基哌嗪-1-基)-1H,1'H-2,5'-聯(lián)苯并[D]咪唑
英文別名
2,5'-Bi-1H-benzimidazole, 2'-(3,4-dimethoxyphenyl)-5-(4-methyl-1-piperazinyl)-物理化學(xué)性質(zhì)
熔點(diǎn)220 °C
沸點(diǎn)737.3±70.0 °C(Predicted)
密度1.292±0.06 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,2-8°C
溶解度DMSO : ≥ 54 mg/mL (115.25 mM);
酸度系數(shù)(pKa)10.78±0.10(Predicted)
形態(tài)粉末
顏色Light brown to brown
常見問(wèn)題列表
生物活性
DMA 是一種熒光化合物 (λex=340 nm, λem=478 nm)。靶點(diǎn)
IC50: 3.4 μM (HeLa cell), 5.3 μM (MCF7 cell)
體外研究
The newly synthesized bisbenzimidazole derivatives DMA (6c) is evaluated for their cytotoxicity against human tumor cell lines, which are cervix carcinoma cell line (HeLa), breast carcinoma cell line (MCF7) and brain glioma cell line (U87) in comparison to Hoechst. In case of MCF7, the IC 50 is observed at 5.3 μM for DMA. The IC 50 determined in the case of HeLa is 3.4 μM for DMA.