188713-69-1
中文名稱
L-Phenylalanyl-L-leucyl-L-prolyl-L-leucyl-L-isoleucylglycyl-L-arginyl-L-valyl-L-leucyl-L-serylglycyl-L-isoleucyl-L-leucinamide
英文名稱
L-Phenylalanyl-L-leucyl-L-prolyl-L-leucyl-L-isoleucylglycyl-L-arginyl-L-valyl-L-leucyl-L-serylglycyl-L-isoleucyl-L-leucinamide
CAS
188713-69-1
分子式
C68H117N17O14
分子量
1396.76
MOL 文件
188713-69-1.mol
更新日期
2024/12/31 15:15:34
188713-69-1 結(jié)構(gòu)式
基本信息
中文別名
短Α螺旋抗菌肽TEMPORIN A 英文別名
L-Phenylalanyl-L-leucyl-L-prolyl-L-leucyl-L-isoleucylglycyl-L-arginyl-L-valyl-L-leucyl-L-serylglycyl-L-isoleucyl-L-leucinamideL-Leucinamide, L-phenylalanyl-L-leucyl-L-prolyl-L-leucyl-L-isoleucylglycyl-L-arginyl-L-valyl-L-leucyl-L-serylglycyl-L-isoleucyl-
物理化學(xué)性質(zhì)
密度1.30±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)12.94±0.46(Predicted)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
Temporin A 是從 Rana temporaria 皮膚中分離得到的一種短α螺旋抗菌肽。Temporin A 對(duì)廣譜革蘭氏陽性菌有效。Temporin A 直接與微生物的細(xì)胞膜相互作用，在抗菌濃度下對(duì)紅細(xì)胞無毒。Temporin A 還具有抗真菌活性，可對(duì)抗酵母樣白色念珠菌。體外研究
Temporin A (TA) is a small, basic, highly hydrophobic, antimicrobial peptide amide (FLPLIGRVLSGIL-NH2) found in the skin of the European red frog, Rana temporaria . It has variable antibiotic activities against a broad spectrum of microorganisms, including clinically important Methicillin-sensitive and -resistant Staphylococcus aureus as well as Vancomycin-resistant Enterococcus faecium strains.