1884420-36-3
中文名稱
Terlipressin Diacetate Salt
CAS
1884420-36-3
1884420-36-3 結(jié)構(gòu)式
常見問題列表
生物活性
Terlipressin acetate 是一種具有血管活性的加壓素類似物，也是一種高度選擇性的加壓素 V1 受體激動劑，可減少內(nèi)臟血流量和門脈壓力并控制急性靜脈曲張破裂出血。Terlipressin acetate 具有抗炎和抗氧化作用，可用于肝腎綜合征和耐去甲腎上腺素的敗血性休克的研究。靶點
Vasopressin V1 receptor
體外研究
Terlipressin (25 nM; 24-72 hours; IEC-6 cells) treatment significantly improves cell viability, proliferation and apoptosis in IEC-6 cells.
Terlipressin inhibits the secretion of TNF-α and 15-F2t-isoprostane from IEC-6 cells following oxygen and glucose deprivation/re-oxygenation (OGD/R). Terlipressin administration following OGD attenuates OGD/R-induced cell damage via the PI3K signaling pathway.
Cell Proliferation Assay
| Cell Line: | IEC-6 cells induced by oxygen and glucose deprivation/re-oxygenation (OGD/R) |
| Concentration: | 25 nM |
| Incubation Time: | 24 hours, 48 hours, 72 hours |
| Result: | Significantly increased the proliferation of IEC-6 cells. |
體內(nèi)研究
Using a mouse nonlethal hepatic ischemia-reperfusion (IR) model, Terlipressin administration significantly ameliorates IR-induced liver apoptosis, necrosis and inflammation.