188196-22-7
188196-22-7 結(jié)構(gòu)式
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生物活性
Frakefamide 具有有效的止痛作用，是選擇性的 μ受體的外圍激動劑。Frakefamide 不能透過血腦屏障，進(jìn)入中樞神經(jīng)系統(tǒng)。體內(nèi)研究
Frakefamide (LEF576) yields a dose dependent increase in morphine appropriate responding to 50% at the highest dose tested (10 μmol/kg) after infusion durations of 2 min, whereas after 15 min infusions a maximum of 25% morphine appropriate responding was occasioned at 17.5 μmol/kg.